Worldwide fish production continues to go beyond world population growth and fish farming remains the field that grows faster than many other fields (Moffitt & Cajas-Cano, 2014). After 40 years of constant growth in fish farming-related production, over half of the fish used globally is supplied by this sector and most of the aquatic products create an important food source with increasing economic importance (Moffitt & Cajas-Cano, 2014). Diseases of water living organisms like fish are the most restriction to the progress of the worldwide fish farming related manufacturing and commerce. Moreover, malnutrition and environmental stressors may affect fish growth and ability to defend against infections (Meena et al., 2013). Antimicrobial agents such as oxytetracycline, amoxicillin, etc. have been broadly used to eliminate infections related to various microbes such as Aeromonas hydrophila (Depaola et al., 1995). Excessive usage of antimicrobial agents in fish farms provides a selective pressure generating drug-resistant bacteria in addition, transportable resistance genes in fish microbes (Heuer et al., 2009). Resistance genes may possibly broadcast by horizontal gene transmission and become human pathogens or drug-resistant pathogens and the occurrence of resistance to these antimicrobial