The aim of this review is to provide a comprehensive overview of the direct trifluoromethylation of olefinic C–H bonds with special attention on the mechanistic aspects of the reactions.
Aldimines, generated in situ from 4-[2,2-bis(trimethylsilyl)ethenyl]benzaldehyde and aromatic amines, undergo Mannich-type reactions with cyclic and acyclic ketones. The one-pot reaction is efficiently catalysed by zirconium oxychloride (ZrOCl 2 .8H 2 O) at room temperature. β-Amino carbonyl compounds containing bis(trimethylsilyl)ethenyl groups are obtained in acceptable to good yields with moderate to high stereoselectivity under solvent-free conditions.
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