Corona virus Disease (COVID-19) began with a report on December 31, 2019, in Wuhan City of China about pneumonia cluster cases that have not yet been identified. The number of COVID-19 cases has increased and has spread to almost all. The World Health Organization (WHO) has stated that COVID-19 is an international health problem and established as a pandemic. COVID-19 case in Indonesia was first reported on March 2, 2020, and spread in 34 provinces in Indonesia. Treatment and vaccination for the prevention of COVID-19 are still in the process of research. So far preventive measures such as maintaining distance, wearing masks, improving the immune system, and hand hygiene are expected to break the chain of transmission of COVID-19. The COVID-19 socialization aims to provide adequate information to the public about the dangers and efforts to prevent COVID-19 that can be carried out by individuals and the community. The socialization was held in Koja Village, North Jakarta on March 8, 2020. The activity was carried out by the Regional Management of Keluarga Alumni Universitas Gadjah Mada (KAGAMA) DKI Jakarta in collaboration with the Health Sub-Department and the Koja District Government, North Jakarta. The main part of the activity is the delivery of COVID-19 material followed by interactive discussions between participants and resource persons. Individual and community prevention efforts are very important in reducing the number of cases and breaking the chain of transmission so that cases do not increase.
Most infectious diseases in the world are zoonotic diseases. Zoonotic diseases are now a public health problem that is taking the world's attention because it can cause a pandemic. Zoonotic pandemic diseases can have a very large impact on people's social and economic life. This article is a literature review of the approach of one health concept in addressing the spread of zoonotic diseases in Indonesia. Data collection is carried out through research libraries in the form of scientific journals, books, articles in mass media, and online media. Improving the world of livestock in Indonesia has an impact on humans and the environment. This can increase the risk of transmitting various infectious diseases from animals to humans. The spread of disease occurs quickly and can reach areas not limited by cities, islands, even continents. Zoonotic diseases are closely related to animals and humans, so the planning and control efforts undertaken must involve many people in charge, especially in the animal, human and environmental health sectors. Starting from the joint vigilance, the concept of One Health was born. One health approach needs to involve cross-sectoral and cross-disciplinary by integrating professional concepts in animal health and human health. The concept of one health comprehensively looks at the components related to the process of emergence and spread of zoonotic diseases so that the picture of the disease is more complete and makes it easier to overcome.
Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into osteocyte, chondrocyte, and adipocyte. MSCs are promising candidates for a regenerative disease therapy because of their ability to selfrenewal and multi-lineage differentiation. MSCs can be isolated from bone marrow (BM), adipose tissues, Wharton jelly, placenta, dermis, and dental pulp. The aim of this study was to compare isolation of bone marrow MSCs from femur and tibia of Swiss Webster mice. It was an in vitro laboratory experimental design. Mice BMMSCs were isolated from mice femur and tibia bone marrow with flushing methods. Mice femur and tibia were immersed in povidone-iodine solution and alcohol 70 % to bones decontaminated and removed the attached fat and connective tissue. Both ends of the bone are cut and flushing with culture medium. The cells suspension incubated in 5 % CO2 incubator. Characterization of mBMMSCs was done by observed cells number. Differentiation potency of MSCs into osteocyte, chondrocyte, and adipocyte were tested using the commercially available kit with staining by alizarin red, alcian blue and oil red O. SPSS with independent t-test. The results showed that cells number of mice BMMSCs after first passage from tibia is higher than femur. Both of mice MSCs from femur and tibia can differentiate to osteocyte, chondrocyte, and adipocyte. mBMMSCs can be isolated from femur and tibia with same ability of differentiation to osteocyte, chondrocyte, and adipocyte.
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