Non-alcoholic fatty liver disease (NAFLD) is considered as a common cause of chronic liver disease. It is potentially progressive towards non-alcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis and its complications including hepatocellular carcinoma (HCC). So, the need for predictive factors of NAFLD is important. Among the different serum markers in NAFLD, serum uric acid (SUA) has emerged as a possible predictor of severity of liver damage. This observational cross sectional study was carried out involving 100 patients from the department of gastroenterology, BSMMU, Dhaka, with the intention to determine the association of serum uric acid (SUA) level with non-alcoholic fatty liver disease. Among them, 55 were having NAFLD; and 45 subjects without NAFLD were considered as control. The diagnosis of NAFLD was based on the guidelines for the assessment and management of NAFLD in the Asia-pacific region. Serum uric acid, liver enzymes, glycaemic status, serum lipid profile and anthropometric measurements were compared between NAFLD group & control. The mean age was found 41.34 + 10.88 years in both the groups. Male were 62% & female were 38% among the study population. Forty percent of the study subjects were overweight, 23% were obese and 37% had normal body weight. NAFLD patients had significantly higher serum uric level (6.9 + 0.89 mg/dl) in comparison to non-NAFLD group (4.3 +0.87 mg/dl). The study showed that serum uric acid level was significantly associated with NAFLD. Serum uric acid may be used as a useful additional marker to assess the risk of development of NAFLD in the clinical setting of metabolic syndrome. BSMMU J 2021; 14(4): 125-131
Background: Non-alcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome (MS) such as hypertension, type 2 diabetes mellitus, dyslipidaemia and obesity. NAFLD is considered as hepatic manifestation of metabolic syndrome (MS). Objectives: The aim of this study was to see the pattern of lipid profile and blood pressure in NAFLD patients. Materials and methods: This cross sectional study was carried out in the department of gastroenterology, BSMMU, Dhaka, Bangladesh from October 2016 to March 2017. A total of 100 patients included in this study underwent abdominal ultrasonography after excluding known case of liver disease with other etiology. Results: The study population were categorized as NAFLD and normal group on the basis of abdominal ultrasonography. NAFLD and normal subjects were 55% and 45% respectively. The mean age was 41.34 + 10.88 years. Male were 62% and 38% were female.40% of study subjects were overweight, 23% were obese and 37% had normal bodyweight. Body mass index (BMI) was higher in NAFLD group; 25.10 ± 1.75 vs 21.64 ± 2.62 , P < 0.001). Dyslipidemia was present in 47% of study population. Total cholesterol (TC) (195.5±45.98 vs 140.33±47.86 mg/dl, P < 0.001), Low density lipoprotein-cholesterol (LDL-C) (120.28±43.95 vs 95.15±44.90 mg/dl, P < 0.001) and Triglyceride (TG) (230.50 ± 48.96 vs 148.40±46.43 mg/dl , P < 0.001) was higher and High density Lipoprotein (HDL) (32.69±5.49 vs 39.91±5.74 mg/dl, P < 0.001) was lower in NAFLD group in comparison to normal group. Systolic and diastolic blood pressure (BP) was also significantly higher in NAFLD group (135±12 vs 121±9 mm Hg , P < 0.001) and 82±4 vs 74±3 mm Hg (P < 0.001) respectively. Conclusion: Higher prevalence of dyslipidemia was found in NAFLD patients. TC, LDL-C , TG and blood pressure was significantly higher in NAFLD patient in comparison to normal group. J Shaheed Suhrawardy Med Coll 2021; 13(1): 68-74
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