Parabens are group of preservatives chemical compounds used in cosmetics, personal hygiene product, food products and pharmaceuticals. In this study the hepatorenal toxicity due to exposure to paraben was evaluated. In this study design Twenty-four of albino rats experimentally used. Butyle paraben (BP) orally was given to animals 180 days in dose of 4.6 mg\kg.bw which equal to10 % of the LD50 of BP. The extract of Mushroom was given by stomach tube in dose of 10 mg/kg/day for six 180 days. Exposure to Parabens exhibited histopathological and biochemical alterations. In the line of biochemical analysis BP induced toxic changes in both liver and kidney, the hepatic cellular enzymes concentrations (AST, ALT), Bilirubin, urea and creatinine were raised. In contrast plasma proteins were decreased in comparison to the control group. In renal and hepatic tissues BP administration induced vascular congestion as well as necrosis in the hepatorenal epithelium. Both the biochemical and histopathological alteration was improved after giving mushroom extracts in comparison to BP given group. In conclusion, mushroom extracts exhibited biochemical and histopathological improvement in liver and kidney against the toxicity by Butylparaben.
Deltamethrin (DM) is one of the most environmental and industrial pollutants that are toxic to humans, animals, fishes, and birds. The most common sources of human and animal exposure to deltamethrin (DM) are polluted water and food. This study was done to evaluate the nephrohepatic toxicity of deltamethrin. Twenty-four male rats were used. The first group was used as a control. The second and third groups were given deltamethrin orally in a dose of 1/10 % of the LD50 equal to 0.6mg\kg bwt alone plus royal jelly (RJ) at a dose of 100 mg/kg/day for two months, respectively. Oral administration of DM-induced biochemical and histopathological alterations. DM toxicity exhibited changes in the liver and kidney function tests manifested by an increase in AST, ALT, urea, uric acid and creatinine with no changes noticed in plasma proteins when compared to the control group. Giving RJ ameliorated the hepatorenal toxicity by causing recovery in both liver and kidney functions in comparison to DM given group. Pathologically, severe degenerative and necrotic changes in livers and kidneys were present in the deltamethrin group, where it improved to moderate to mild lesions with a protective royal gel substance. This study concluded that royal gel substance has been shown to benefit in lower down the side effects and increasing the rate of improvement of injury induced by deltamethrin.
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