Ameliorative Effect of Mushroom Extracts against Butyl Paraben Induced Toxicity in Liver and Kidney in Female Albino Rats.

Abstract

Parabens are group of preservatives chemical compounds used in cosmetics, personal hygiene product, food products and pharmaceuticals. In this study the hepatorenal toxicity due to exposure to paraben was evaluated. In this study design Twenty-four of albino rats experimentally used. Butyle paraben (BP) orally was given to animals 180 days in dose of 4.6 mg\kg.bw which equal to10 % of the LD50 of BP. The extract of Mushroom was given by stomach tube in dose of 10 mg/kg/day for six 180 days. Exposure to Parabens exhibited histopathological and biochemical alterations. In the line of biochemical analysis BP induced toxic changes in both liver and kidney, the hepatic cellular enzymes concentrations (AST, ALT), Bilirubin, urea and creatinine were raised. In contrast plasma proteins were decreased in comparison to the control group. In renal and hepatic tissues BP administration induced vascular congestion as well as necrosis in the hepatorenal epithelium. Both the biochemical and histopathological alteration was improved after giving mushroom extracts in comparison to BP given group. In conclusion, mushroom extracts exhibited biochemical and histopathological improvement in liver and kidney against the toxicity by Butylparaben.

A study on assessing the toxic effects of ethyl paraben on rohu (Labeo rohita) using different biomarkers; hemato-biochemical assays, histology, oxidant and antioxidant activity and genotoxicity

“…The alterations in gills, like epithelial lifting, hyperplasia, and fusion of epithelial cells, were also reported by Camargo and Martinez [ 47 ]. A similar alteration in histology of the gills after exposure to paraben, as recorded by Beriry, Atef [ 43 ] supports our present study.…”

“…The results of serum biochemical showed that all these parameters were elevated significantly as compared to the control group. These results were supported by the findings of Beriry, Atef [ 43 ] and Darbre and Harvey [ 44 ]. The increases in liver enzymes occur directly in response to liver toxicity caused by ethylparaben in hepatocytes.…”

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

“…Changes in kidney structure can influence urea levels. 16 In our research, various findings were observed in the examined kidney tissues, including glomerular atrophy, tubular degeneration, and structural deterioration. Therefore, it is speculated that the decreased serum urea value is a result of kidney impairment.…”

“…14 Studies on parabens and endocrine-disrupting chemicals have reported increased serum ALT and AST levels. 3,[15][16][17] The most common reason for elevated serum ALT levels is likely plasma membrane injury, with ALT activity increasing significantly during hepatocyte damage and necrosis. 17 In our research, necrotic areas were observed in the dose groups.…”

“…This finding is consistent with previous studies conducted on parabens, which also reported a decrease in serum albumin levels. 16 Disorders in kidney function can lead to alterations in blood urea levels, resulting in either an increase or decrease. Changes in kidney structure can influence urea levels.…”