No abstract

Intermittent fasting (IF) describes a variety of eating patterns during which no or few calories are consumed for certain time, which can range from twelve hours to some days, on a frequent basis. In recent years, IF became popular as a possible new paradigm for weight loss and inflammation reduction, as well as numerous health benefits. In this review, we incorporated various aspects of fasting, especially the effects of intermittent fasting diet (IFD) on lipid profile and inflammation as well as its effect on the body mass index and the glucose metabolism in non-diabetic people. Liver, cardiovascular and central nervous systems physiological responses are illustrated as well. An IFD may provide a huge metabolic benefit by improving glycemic control, insulin resistance, and adipokine concentration with a discount of body mass index in adults. Also, IF protocol helps improving several physiological functions thus inducing longevity and minimizing illness. Moreover, alternate day fasting (ADF) is considered as good protocol of food intake therapy for persons with non -alcoholic fatty liver disease (NAFLD), which can help in loss of weight and treatment of dyslipidemia within a relatively short period of time (a month to three months), and reduce cardiovascular risk factors. In conclusion, IF is suggested during the fight against many diseases as cancer, diabetes and central nervous system (CNS) disorders.

Obesity, especially the visceral one, insulin resistance, atherogenic dyslipidemia, and hypertension are considered metabolic disorder, but the constellation of at least three of these metabolic disorders can be identified collectively as metabolic syndrome (MetS), The prevalence of this syndrome is mostly driven by the current changes in the social environment, behavior, and lifestyle, which is generally called a sedentary lifestyle since more and more individuals are being diagnosed with it.The main target of this article is the collection of some available known published papers aboutthe evaluation of dietary induction of metabolic syndrome accompanied with MTHFR rs1801133(MTHFR-Ala222Val)Singlenucleotide polymorphism (SNP) and the potential preventive effect of metformin or curcumin in male albino rat with an induced MetS as a novel method using many biochemical, Anthropometrical, and molecular biological tests including the embedding the RFLP technique for identification of the presence of the target SNP and its role both in the induction of this gene polymorphism and its role in MetS treatment.