Aim: We studied the response to high doses of egg yolk containing antisecretory factor (B221 â , Salovum â ) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan.Methods: In a randomised, placebo-controlled trial, 36 children aged 7 to 60 months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum â or placebo groups. Initially, 16 grams of Salovum â or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8 g every 5 h until recovery. The number and consistency of stools were recorded.

Peroral high doses of Salovum® rapidly and safely counteract diarrhea in children followed by a diarrhea-free period of 6 weeks.

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