Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo‐controlled, randomised study

Abstract

Aim: We studied the response to high doses of egg yolk containing antisecretory factor (B221 â , Salovum â ) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan.Methods: In a randomised, placebo-controlled trial, 36 children aged 7 to 60 months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum â or placebo groups. Initially, 16 grams of Salovum â or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8 g every 5 h until recovery. The number and consistency of stools were recorded.

Antisecretory Factor May Reduce ICP in Severe TBI—A Case Series

“…The dosage of Salovum and the dosage interval were chosen from the lower ranges of dosages as reported from prior human trials with Salovum (19).…”

High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment

“…We have previously shown that peroral treatment of children with Salovum effectively counteracts diarrheal diseases of various etiologies (Zaman et al, 2014;Zaman et al, 2013;Zaman et al, 2007). A registration of the children's health status, with a focus on diarrheal diseases recurrence during the diarrhea rehabilitation period has, however, not been performed.…”

Secretory diarrhoea: mechanisms and emerging therapies

“…A modified egg-yolk product enriched with antisecretory factor (Salovum®, AS-Faktor AB, Sweden) reduced the duration of acute and prolonged (>7 days) diarrhoea in a randomized, placebo-controlled trial in children aged 7–60 months. 129 Further clinical and mechanistic studies are needed for this promising drug.…”