Methods. We report the case of a 73-year-old Saudi female who presented with severe thrombocytopenia and mild autoimmune hemolytic anemia associated with brucellosis. The coexistence of published cases of two hematological disorders with brucellosis is rare. Results. Despite the initial treatment with eltrombopag and intravenous immunoglobulin (IVIG), our patient’s platelets count remained low and significantly improved after initiation of brucellosis treatment in the form of rifampicin and doxycycline. Discussion. We conclude by reviewing the case that in many parts of Saudi Arabia, brucellosis remains a prevalent infection. Hence, it should be considered as a possible diagnosis in febrile individuals with no localizing indications and the presence of severe thrombocytopenia in acute febrile illness. Although it is a rare association, it could be related to brucellosis. Conclusion. This is our region’s first published case of severe thrombocytopenia and mild autoimmune hemolytic anemia associated with brucellosis. It contributes to the literature on the successful use of rifampicin and doxycycline to treat hematological disorders associated with brucellosis.
Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), both are serious health risks. In western countries, VTE affects about 114 to 184 people per 100,000. Asian populations have a significantly lower incidence than western populations. The true incidence of VTE is still not well documented in Saudi Arabia (KSA). There are different major risk factors especially in hajj season that predispose a person to thrombosis. The mortality rate of autopsy-based pulmonary embolism reaches up to 30%.
Methods: This single-centered retrospective descriptive study was done in security forces hospital Makkah, Saudi Arabia during hajj period (30 days) for consecutive three-year. All admitted confirmed DVT and PE patients (N=32) of both genders with age >14 years were included. Patients’ data were extracted from the electronic medical record. Data were analysed by SPSS version 23.
Results: Deep venous thrombosis (DVT) was developed in 67.7% while 19.3% of patients suffered from pulmonary embolism (PE) out of a total of 32 subjects. Females were more affected by 18 (56.3%) than males by 14 (43.8%). The mean age of patients was 51.78 years (SD ±16.21). A statistically significant association (p<0.005) between provoked VTE status and age, immobility, and history of surgery was seen. There was no mortality documented in this study.
Conclusions: This study provides insights into hajj period hospital admitted patients’ frequency of VTE, changing patient profiles, management strategies, and subsequent outcomes in patients with venous thromboembolism. There is a need for greater awareness of VTE prophylaxis about its prevention, especially in hajj season.
Introduction: COVID-19 disease is currently pandemic, and its prevalence in Saudi Arabia is concerning. The SARS-CoV-2 virus primarily affects the lungs, but it also affects the haematopoietic system. The atypical lymphocytes on peripheral blood film that have a distinct morphological appearance were of particular interest in this study. Our goal was to see a link between atypical lymphocytes and COVID-19 patient mortality. Methods: This four-month single-centered prospective descriptive study was conducted in Makkah, Saudi Arabia. COVID-19 patients of both genders were randomly selected based on inclusion criteria. The data from the patient’s electronic medical record was extracted. All patients’ peripheral blood film parameters were recorded on days 3, 7, and 14 after admission. The statistical data was analysed using SPSS version 23. The Fisher’s exact test was used to determine the relationship with mortality. A p value of 0.05 was considered significant. Results: The total number of cases enrolled in the study was 226. The patients’ average age was 58 years (SD 0.5289). On the third day of admission, 88.2 % of patients with COVID-19 had atypical lymphocytes, with a mean of 2.35 ± 0.927. A significant correlation (p < 0.001) exists between atypical lymphocytes decreasing percentage number on the 3rd, 7th, and 14th days of admission and death.
Conclusion: The decrease in the number of atypical lymphocytes on peripheral blood film has a significant association with the patients’ mortality. This fact can be used to develop a tailored management strategy based on the observation of peripheral blood film.
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