This study was undertaken to study the changes of the blood constituents of rats fed different proteins (lupinus termis, Guiza 1, 2 and balady; fenugreek seeds, raw, roasted, and germinated). The total serum protein for animals fed casein was slightly higher than those fed other proteins. Total serum protein of animals fed lupinus termis, roasted and germinated fenugreek was higher than those fed raw seeds. The albumin/globulin ratios showed a similar trend. The ratio of nonessential to essential free serum amino acids of rats fed non-protein diet was higher than those fed protein. Lupinus termis and fenugreek seeds are good sources of protein. Treatment of seeds either by heat of germination improves the nutritive value of the proteins.
Background: Chronic low back pain (LBP) affects about 45% of the population, it is treated conservatively, and if failed, we use invasive methods, as radiofrequency neurotomy (RF). Objective: to evaluate the efficacy, safety, and outcome of RF in patients with chronic LBP. Patients and Methods: This prospective study included patients with chronic LBP lasting ≥3 months. We performed RF to the included participant, moreover, we assessed the chronic LBP by visual analogue score, the improvement of the daily activities, and the safety immediately after the procedure, after one week, after one month and after three months. Results: We included 40 patients with chronic LBP not responding to medical treatment. The average age was 58.28 ±7.2, 13 of them were male. The L4-L5-S1 levels were the most affected (67.5%). The pain score reduced from 8 before the operation to 3 after three months follow up p-value < 0.001. Regarding to Daily living activities, after 3 months the number of patients with normal daily activities was 50 %, and the number of supported patients still only 3 patients p-value < 0.001. Conclusion: RF showed promising results in the management of chronic LBP, it has advantages regarding the long term follow up.
General chemical analysis of some Egyptian legumes (lupinus termis and fenugreek seeds) and biological evaluation for their proteins were investigated. Results showed that lupinus termis and fenugreek seeds have high protein contents (with the exception of germinated fenugreek). They are good sources of calcium and phosphorus. Raw seeds gave low PER and NPR values. However, these values increase after roasting or germination.
HCC is a neoplasm of high degree of malignancy and quite unfavorable prognosis. In Egypt, HCC is now a common malignancy which usually develops on top of liver cirrhosis of viral origin in 82% of cases. Egypt has one of the highest prevalence rates of HCV infection in the world. Both HCV and HBV infections increase the risk of HCC. Treatment of HCC depends mainly on extent of disease, the presence or absence of cirrhosis as well as degree of hepatic dysfunction. Most patients who show evidence of liver failure are seldom suitable for any active treatment. HCC is found to be resistant to conventional chemotherapy, cytabine analogues (gemcitabine) is a new anticancer agent with acceptable toxicity profile which demonstrated antineoplastic activity in many solid tumors. Few clinical trials have shown that gemcitabine appears to have antitumor activities for HCC. This is a clinical trial done on 60 patients with HCC to evaluate the role of gemcitabine with de Gramont regimen. Overall response rate was 10% (5% CR and 5% PR), 20% SD and DP in 70% of patients, TDP was two months. Toxicity was accepted with grade III and IV hepatic toxicity in 10% of patients and grade III and IV hematologic toxicity in 6.6%. Although this regimen has an acceptable toxicity profile, but it did not add much to outcome of HCC like most chemotherapeutic combinations which also carry poor response and survival rates. Studies using newer regimens and targeted therapies as well as efforts to prevent HCV and HBV infections are required to combat such aggressive disease.
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