ABSTRACT:Microsphere of Enalapril malate were formulated by ionotropic gelation technique using like sodium alginate, HPMC, carbopol 940, Guar gum, Xanthum gum in different ratios. Prepared micropeletes were evaluated for flow behavior, drug entrapment efficiency, in-vitro dissolution and stability studies, including scanning electron microscopy and optical microscopy. Of the ten formulations prepared and evaluated formulations F3 containing HPMC 100 and carbopol found to show satisfactory results. The release of the drug from the micropeletes was found to be following Non-Fickian diffusion, Drug diffusion coefficient and correlation coefficient were also assessed by using various mathematical models. From the study it was concluded that prolonged release Enalapril malate micropeletes can be achieved with success using ionotropic gelation technique.
The present study utilised the direct compression method to formulate orodispersible tablets of Clozapine using various natural superdisintegrants such as plantago Ovata mucilage and unripe banana powder at various concentrations (2 percent, 4 percent, 6 percent, and 8 percent) and a control formulation (without superdisintegrants). To increase the mouth feel, microcrystalline cellulose and mannitol were employed. The pre compression characteristics of the prepared formulations were determined, and all formulations were found to have satisfactory flow qualities. After compression, the tablets were examined for hardness, friability, homogeneity of drug content, wetting time, water absorption ratio, in vitro dispersion time, and dissolving studies. CLZ4 containing 8% plantago ovata mucilage had a faster in vitro dispersion time (9 seconds), disintegration time (13 seconds), wetting time (10 seconds), and drug release rate (99%) in 30 minutes. Stability analyses conducted on the promising formulations revealed no significant changes in drug content or in vitro dispersion time. There are no drug-excipient interactions, as determined by IR spectroscopy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.