Microencapsulation of Enalapril Using Different Polymers by Ionotropic Gelation Techinique

Abstract

ABSTRACT:Microsphere of Enalapril malate were formulated by ionotropic gelation technique using like sodium alginate, HPMC, carbopol 940, Guar gum, Xanthum gum in different ratios. Prepared micropeletes were evaluated for flow behavior, drug entrapment efficiency, in-vitro dissolution and stability studies, including scanning electron microscopy and optical microscopy. Of the ten formulations prepared and evaluated formulations F3 containing HPMC 100 and carbopol found to show satisfactory results. The release of the drug from the micropeletes was found to be following Non-Fickian diffusion, Drug diffusion coefficient and correlation coefficient were also assessed by using various mathematical models. From the study it was concluded that prolonged release Enalapril malate micropeletes can be achieved with success using ionotropic gelation technique.

Response Surface Method Assisted Fabrication and Characterization of Optimized Aceclofenac Loaded Microspheres Inculcated with Multivariate Polymers

“…The drugs having short elimination half-life were selected as most acceptable candidates for CR formulations [1,2] . In present research work we had tried to develop and characterize a CR system with improved micromeritic properties of pure drug by formulating microspheres, that are solid, approximately spherical particles (1-1000 µm) containing uniform distribution of drug and polymers, either in matrix or encapsulated form [3] .…”