Pemberdayaan masyarakat terhadap pencegahan Covid 19 merupakan upaya yang dilakukan oleh seluruh masyarakat agar mampu berperan mencegah penularan Covid 19. Dengan adanya kegiatan ini masyarakat Semoyang dapat melakukan tindakan yang tepat dalam menghadapi Covid 19. Tujuan kegiatan pengabdian masyarakat ini adalah memberikan Pendidikan Kesehatan tentang pentingnya peran masyarakat memutus mata rantai penularan Covid 19 di Desa Semoyang Lombok Tengah. Metode yang digunakan adalah ceramah, diskusi, simulasi dan dilakukan wawancara beberapa peserta serta pre/pos test. Kegiatan di evaluasi dengan menyebarkan kuesioner kepada para peserta kegiatan. Materi simulasi yang diberikan yaitu cuci tangan enam langkah, penggunaan masker dan etika batuk bersin yang tepat. Hasil kegiatan menunjukkan terjadi peningkatan pemahaman dan keterampilan tindakan terhadap materi COVID-19, cuci tangan 6 langkah dan etika batuk bersin yang tepat. Peningkatan terjadi signifikan pada kategori pemahaman tentang materi dengan kategori baik yaitu pre-test 8 peserta (28%), meningkat menjadi 17 peserta (49%) saat post-test. Hasil post-test simulasi menunjukkan Sebagian besar peserta yaitu 75% mampu melakukan tindakan cuci tangan enam langkah yang benar dan etika batuk bersin yang tepat. Hasil wawancara ke beberapa peserta menunjukkan peserta memiliki tambahan metode yang diterapkan sangat efektif untuk melatih keterampilan peserta dalam cuci tangan dan etika batuk bersin yang benar.
Excessive salt consumption is one of the hypertension factor leads to kidney disease, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor leads to the decrease of blood pressure, but it also activates peroxisome proliferator activated receptor gamma (PPAR-γ), inhibits transforming growth expression factor of beta-1 (TGFβ-1) and increases bone morphogenetic protein-7 (BMP-7). Whether telmisartan increases BMP-7 expression of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The expression of BMP-7 was measured by immunohistochemistry technic. Data were expressed as mean ± standard deviation. They were analyzed by parametric (ANOVA) or nonparametric (Kruskal-Wallis) test. A value of p<0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular BMP-7 protein expression were higher in telmisartan-treated Wistar rats group than negative control group (p<0.05). In conclusion, intraglomerular and extraglomerular BMP-7 protein expression were higher in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group.
Pepper elder (Peperomia pellucida) and green chiretta (Andrographis paniculata) are plants that have been used empirically to reduce fever. Fever is a symptom of a disease characterized by a significant increase in body temperature. This study aimed to determine the antipyretic effect of the combination of pepper elder herbal extract (P. pellucida) and green chiretta herbal extract (A. paniculata) (80:20) in the male house mice (Mus musculus). Extraction was conducted through maceration using ethyl acetate solvent. The total of 25 male mice were divided into 5 groups, namely a negative control group (Na-CMC 1%), a positive control group (paracetamol), and a treatment group induced by a combination of pepper elder herbal extracts and green chiretta herbal extract at the dose of (80 + 20), (40 +10), and (20 + 5) mg/kg BW. DPT vaccine 0.2 ml was used intramuscularly as a fever inducer. The observation was carried out at 30, 60, 90, and 120 minutes after treatment. The data obtained were analyzed using one-way ANOVA followed by the LSD test to determine the differences between groups. The results showed that variations in the dose of the combination of pepper elder and green chiretta herbal extracts had an antipyretic effect where the most effective dose was (80 + 20) mg/kg BW due to its stable temperature reduction power and effectiveness that are equivalent to paracetamol. The combination of suruhan herb extract (P. pellucida) and sambiloto herb (A. paniculata) has potential as an antipyretic
Diuretics are compounds or drugs that can increase urine volume. This study focused on exploring the activity and concentration of ethanol extract of lamtoro leaves (Leucaenaleucocephala L.) as a diuretic in male house mice (Musmusculus) using experimental research. The method used was to observe the physical activity of urine produced for 120 minutes. Lamtoro leaves extraction was done by maceration using solvent ethanol, then phytochemical screening tests. The screening results stated positively contained alkaloids, flavonoids, terpenoids, and tannins. The animals used were 25 house mice, divided into 5 groups. Group 1 was given Na-CMC 1% w/v suspension, group 2 with furosemide suspension 0.0041% w/v, group 3 with 25% w/v lamtoro leaf ethanol extract, group 4, ethanol extract 50% w/l lamtoro leaf , and group 5 was ethanol extract 75% w/v of lamtoro leaves. Urine volume of the house mice was measured at 15, 30, 45, 60, 75, 90, 105, and 120 minutes.
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