PURPOSE The aim of the study was to evaluate the efficacy of hysterectomy in the control of pelvic disease in patients with post-irradiated residual cervical cancer. PATIENTS AND METHODS Forty patients were treated at either National Institute of Cancer Research and Hospital (NICRH) or Delta Cancer Hospital in Dhaka, Bangladesh, with International Federation of Gynecology and Obstetrics stage IIB to IIIB disease with residual disease after the following: either concurrent chemoradiation with or without brachytherapy, induction chemotherapy and external-beam radiotherapy (EBRT) with or without brachytherapy, or only EBRT. Patients were treated by either radical hysterectomy or extrafascial hysterectomy. RESULTS From 2009 to June 2013, 55 patients were evaluated for central residual disease on their presentations to NICRH or Delta Hospital. Patients with distant recurrences after primary radiation were excluded. Forty patients had invasive cancer on biopsy and underwent either radical hysterectomy or extrafascial hysterectomy. Surgery was performed 14 to 18 weeks after the initial treatment. Of the 29 women who underwent extrafascial hysterectomy, four (13.8%) developed recurrent disease, and one died; none of the 11 patients treated by radical hysterectomy experienced recurrences during the study period. Morbidity was increased in patients who underwent radical hysterectomy. Overall 90% of patients (36 of 40 patients) who underwent surgery had no evidence of disease at 5 years of follow-up. CONCLUSION Surgery is a viable treatment option for patients with residual cervical cancer after radiation. Radical hysterectomy after radiation is more morbid but has better tumor control than extrafascial hysterectomy.
Results:The changes in primary outcome variable (PEFR) in both groups before and after intervention was 179.19 ± 33.27 vs. 197.52 ± 57.01 liters/min and 184.81 ± 59.65 vs. 202.83 ± 64.76 liters/min respectively, which was statistically highly significant (P= 0.001). Similar significant changes were also observed in case of secondary outcome variables. Conclusion:Bronchodilator response to salbutamol in mild or moderate acute asthma in children is similar when equal amount of drug is delivered either through an MDI with spacer or a DPI.
Aim: This study was aimed to find out the mismanagement of infantile masturbation and the outcome of the cases who were treated with anti-epileptic drugs. Study Design: Retrospective. Place and Duration of Study: This study was conducted at outpatient department of Rehabilitation and Neurology unit of Dr. M R Khan Shishu Hospital and Institute of Child Health, Dhaka Bangladesh, between 2013-2022. Methods: Data were collected from records which included socio-demographic data and clinical features of masturbation in children. Data related to treatment was also collected and their outcome was observed. Results: Among 50 patients, majority (74%) had age of onset between 12-36 months of age. Mean age was 43±26 months, the range was between 4 months to 84 months. Female were predominant (60%). Most of the children came from urban area (86%) and belong to nuclear family (78%). They presented with stereotype movement of variable duration and there was no alteration of consciousness. Prone positioning was more frequent than prone to supine position (78% Vs 18%). There was no laboratory and EEG abnormalities among the cases. Thirty two percent patients were treated with anti-epileptic drugs from outside and among them 2 (12%) was given sodium valproate and rest 14 (88%) were treated with phenobarbitone. But there was no clinical improvement in these cases. Conclusion: Use of anti-epileptic drugs was not associated with any clinical improvement in children with infantile masturbation.
Background : Acute viral encephalitis is a world-wide health problem with severe morbidity, significant mortality and a high incidence of residual sequelae in survivors.Objective : To identify the association of clinical features of acute viral encephalitis with mortality and neurodevelopment outcomes.
Background: C-reactive protein (CRP) is the inflammation-responsible protein and a significant rise of the plasma concentration of CRP is pervasive in the progress of ovarian cancer. However, there are few studies that comprehensively evaluate the correlation between CRP concentrations and ovarian cancer and the causal effect remains unknown. With a Mendelian randomization (MR) approach, we were able to investigate the causal relationship between genetically predicted CRP levels and ovarian cancer risk.Methods: Utilizing 32 CRP-related single nucleotide polymorphisms as instrumental variables identified by the latest genome-wide association studies, we investigated the correlation between genetically predicted CRP and ovarian cancer risk using summary statistics from the Ovarian Cancer Association Consortium (25,509 cases and 40,941 controls). The Inverse variance weighted (IVW) method was applied to estimate the causality between genetically elevated CRP concentrations and ovarian cancer risk. To further evaluate the pleiotropy, the weighted median and the MR-Egger regression method were implemented. Subgroup analyses according to different histotypes of ovarian cancer were also conducted.Results: An inverse association was observed between genetically predicted one-unit increase in the log-transformed CRP concentrations and ovarian cancer (OR ¼ 0.93, 95%CI ¼ 0.87-1.00 p ¼ 0.047). When results were examined by histotypes, an inverse association was observed between genetically predicted one-unit increase in the logtransformed CRP concentrations and endometrioid ovarian cancer (OR ¼ 0.80, 95%CI ¼ 0.70-0.91 p ¼ 0.001), low-grade serous ovarian cancer (OR ¼ 0.70, 95%CI ¼ 0.58-0.86 p ¼ 0.001) and serous ovarian cancer (OR ¼ 0.84, 95%CI ¼ 0.74-0.96 p ¼ 0.012). Additionally, the results demonstrated the absence of the horizontal pleiotropy.Conclusions: MR findings provide evidence for a causal relationship between genetically predicted one-unit increase in the log-transformed CRP concentrations and reduced ovarian cancer risk, overall and among specific histotypes. Further studies are warranted to investigate the underlying mechanism.Legal entity responsible for the study: Haoxin Peng.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.