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Summary The present study evaluates the antioxidant and antifungal effects of essential oils (EOs) from Thymus vulgaris, Thymus algeriensis, Mentha piperita, Mentha pulegium, Artemisia herba-alba and Artemisia campestris, on five strains of Fusarium. The chemical composition of EOs of T. vulgaris, T. algeriensis, A. herba-alba, M. piperita and M. pulegium is characterized by a dominance of the family of oxygenated monoterpenes with 73.85%, 59.41%, 70.01%, 60.01% and 87.2%, respectively. On the other hand, the EO of A. campestris showed a diverse composition by similar percentages between all families. The two strains BD17 and INRA 349 were found to be resistant to low concentrations of EOs from T. algeriensis, A. campestris and A. herba-alba, sensitive to EOs of M. pulegium and M. piperita and very sensitive to T. vulgaris EO (0.25 μl/ml). A high antioxidant effect was recorded by T. vulgaris EO in BCB assay with an effective concentration (0.5 mg/ml) 3 to 60 times higher compared to the other EOs tested. This antioxidant capacity of T. vulgaris EO was also recorded with DPPH assay at an EC50=1.41 mg/ml.

Background:: Calamintha nepeta is a plant from the Lamiaceae family that is known for its traditional use to treat diabetes among Algerian populations. However, till now, there has been no research work to confirm this activity. background: Calamintha nepeta is a plant from the Lamiaceae family which is known for its traditional use to treat diabetes in Algerian populations. Until now there have been no research work to confirm this activity. Objectives:: This work aimed to evaluate the amylase inhibitory activity of essential oils and phenolic compounds from both methanolic and aqueous extracts of Algerian Calamintha nepeta (L.). objective: The evalutation of the antiamylatic activity of essential oil, methanolic and aqueous extracts from Algerian Calamintha nepeta (L.). Methods:: The essential oil was obtained by hydrodistillation and analyzed using GC and then GC/MS. Aqueous and methanolic extracts were obtained from the remains of the hydrodistillation. Total phenolic compounds were quantified using the Folin-Ciocalteu method. The amylase inhibitory activity of the extracts was determined by testing their ability to inhibit alpha-amylase. Results:: The extraction yield was 0.67 % (w/w) for the essential oil, and 11.85 and 4.38 % (w/w) for the aqueous and methanolic extracts, respectively. The essential oil analysis revealed that menthone, menthol, pulegone, and pulegone oxide were the main components of the oil. The total phenolic compounds in the aqueous and methanolic extracts were 41.81 and 32.92 mg GAE/g DW, respectively. The extracts inhibited α-amylase activity with IC50 values of 24.46, 31.54, and 115.47 mg/ml for the methanolic extract, essential oil, and aqueous extract, respectively. result: Extraction yield was 0.67 %(w/w) for the essential oil, and 11.85 and 4.38 %(w/w) for the aqueous and methanolic extracts respectively. The essential oil analysis revealed that menthone, menthol, pulegone and pulegone oxide were the main components. Total phenolic compounds for the aqueous and methanolic extracts were respectively 41.81 and 32.92 mg GAE/g. The different extracts showed inhibition activity towards α-amylase with IC50 values equal to : 24.46 ; 31.54 and 115.47mg/ml for the methanolic extract, the essential oil and the aqueous extract respectively. Conclusion:: The different extracts of Calamintha nepeta showed an interesting composition and significant amylase inhibitory activity, emphasizing their successful use in traditional medicine. conclusion: The different extracts of Calamintha nepeta showed an interesting composition, and a significant antimaylatic activity. other: future profound studies are necessary to identify the active molecules

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