Background: Information regarding outcome of dogs undergoing surgical management for insulinoma is based on studies of a small number of dogs.Objectives: To report the outcomes of dogs undergoing surgery as treatment for insulinoma, the prevalence of postoperative diabetes mellitus (DM) in this group and to determine if development of DM can be predicted. Animals: Forty-eight client-owned dogs, with a histopathological diagnosis of insulinoma, from three European referral hospitals. Methods: Retrospective observational study. Dogs were identified from a search of electronic hospital records. Cox's regression was used to determine factors associated with postoperative survival and relapse, and logistic regression was used to determine factors associated with the development of DM. Results: Median survival time (MST) was 372 days (range 1-1680 days), with dogs with stage I disease having the longest survival time. Stage I dogs had MST of 652 days (range 2-1680 days), whereas dogs with either stage II or III disease had MST of 320 days (range 1-1260 days; P = 0.045). Postoperative hyperglycemia was identified in 33% (16/48) of the dogs, of which 9 (19% of the total population) developed persistent DM. No factors that could be used as predictors for development of DM were identified.Conclusions and clinical importance: Stage of disease and postoperative hypoglycemia were associated with greater odds of relapse and decreased survival time; these could be used when discussing prognosis. In this study, postoperative DM developed more commonly than previously reported, but no factors were identified that might be useful predictors.

Objectives Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex, can infect cats and has proven zoonotic risks for owners. Infected cats typically present with a history of outdoor lifestyle and hunting behaviour, and cutaneous granulomas are most commonly observed. The aim of this study is to describe an outbreak of tuberculous disease commencing with six young cats, living exclusively indoors in five different households across England, being presented to separate veterinarians across the UK with a variety of clinical signs. Methods Investigations into the pyogranulomatous lesions, lymphadenopathy and/or pulmonary disease of these cases consistently identified infection with M bovis. Infection was confirmed by PCR, where possible, or was indicated with a positive interferon-gamma release assay (IGRA), where material for PCR was unavailable. Incontact, cohabiting cats were screened by IGRA and follow-up testing was undertaken/advised where results were positive. A lifestyle investigation was undertaken to identify the source of infection. Results Six clinically sick cats and seven in-contact cats were identified with evidence of M bovis infection. Five clinical cases were either too sick to treat or deteriorated despite therapy, giving a mortality rate of 83%. Lifestyle investigations revealed the common factors between clusters to be that affected cats had mycobacterial infections speciated to M bovis, were exclusively indoor cats and were fed a commercially available raw food product produced by a single manufacturer. The Food Standards Agency, Animal & Plant Health Agency, Public Health England and the food manufacturer concerned have been notified/informed. Other possible sources of exposure for these cats to M bovis were explored and were excluded, including wildlife contact, access to raw milk, the presence of rodent populations inside the buildings in which the cats lived and exposure to known infectious humans. Conclusions and relevance Upon investigations, our results provide compelling, if circumstantial, evidence of an association between the commercial raw diet of these cats and their M bovis infections.

Objectives To report clinical and laboratory features, treatment responses and outcome in dogs diagnosed with sterile steroid‐responsive lymphadenitis in the United Kingdom. Materials and Methods Medical records of dogs diagnosed with sterile steroid‐responsive lymphadenitis from 2009 to 2016 at six specialist referral centres were evaluated retrospectively. Results The study included 49 dogs. Springer spaniels appeared to be over‐represented (16 of 49 dogs). Young dogs (median age: 3 years and 9 months) and females (31 of 49) were frequently affected. Clinical presentation was variable, with pyrexia (39 of 49), lethargy (35 of 49) and anorexia (21 of 49) the most commonly reported clinical signs. Lymph node cytology or histopathology demonstrated neutrophilic, pyogranulomatous, granulomatous or necrotising lymphadenitis without a detectable underlying cause in all cases. Because a sterile immune‐mediated aetiology was suspected, all dogs received prednisolone, which was followed by rapid resolution of clinical signs and lymphadenopathy in most cases. Clinical Significance Sterile steroid‐responsive lymphadenitis should be considered in dogs with pyrexia of unknown origin with inflammatory lymphadenopathy if no underlying cause can be found and often responds well to immunosuppressive corticosteroid therapy.

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Two immature Beagles, one nine months old and one six months old, presented with a variety of clinical signs, including pyrexia, lethargy, weight loss and intermittent vomiting and diarrhoea in one Beagle and severe lethargy, haemorrhagic diarrhoea and vomiting in the second. Investigations in both cases demonstrated a serum cobalamin below the detection limit of the assay. Genetic testing confirmed a CUBN:c.786delC mutation in a homozygous state, confirming Imerslund-Gräsbeck syndrome (IGS) in both Beagles. Both Beagles responded rapidly and completely to parenteral cobalamin supplementation. Both dogs are currently normal, receiving cobalamin subcutaneously every two weeks. This is the first report of genetically confirmed IGS in the Beagle breed in the UK.

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Chronic IPO (CIPO) is typically primary, caused by intestinal leiomyositis, and causes intermittent gastrointestinal signs and weight loss. The aetiology of CIPO remains poorly understood but may represent an immune-mediated destruction of intestinal smooth muscle cells of CIPO in the dog using immunosuppressive corticosteroid therapy.

51Angiostrongylus vasorum (A. vasorum) is an important emerging disease of canidae. 52Cardiorespiratory signs are common in affected dogs, therefore thoracic imaging is critical 53 for diagnosing and monitoring disease. Descriptions of thoracic computed tomography (CT) 54 findings in dogs naturally infected with A. vasorum are currently lacking. Aims of this 55 multicentre, retrospective study were to findings in a group of dogs with confirmed disease, 56 determine whether any changes were consistent among dogs, and propose standardized terms 57 for describing thoracic CT findings. Nine UK-based referral centers' clinical and imaging 58 databases were searched for dogs that had a confirmed diagnosis of A. vasorum, and had 59 undergone thoracic CT examination. Eighteen dogs, from seven of the centers, fulfilled the 60 inclusion criteria. The lung lobes were divided into the following three zones and the CT 61 changes described in each: pleural (zone 1), subpleural (zone 2) and peribronchovascular 62 (zone 3). The predominant abnormality was increased lung attenuation due to poorly defined 63 ground glass opacity or consolidation. There were regions of mosaic attenuation due to 64 peripheral bronchiectasis (6/18). Nine/18 (50%) dogs showed hyper attenuating nodules of 65 varying sizes with ill-defined margins. The distribution always affected zone 1,2 with varied 66 involvement of zone 3; this resulted in clear delineation between zones 2 and 3. 67Tracheobronchial lymphadenomegaly was frequently noted. Findings were non-specific and 68there was considerable overlap with other pulmonary conditions. However, authors 69 recommend that A. vasorum be considered a likely differential diagnosis for dogs with a 70 predominantly peripheral distribution of ground glass opacity or mosaic attenuation.