No significant difference in single- or bi-component results was found after the application of tension to tendons. Results are similar regardless of UTE sequence used for acquisition.

A prospective study with 647 gastric cancer was performed. Resected tumor specimens from 647 patients were examined with respect to eosinophil infiltration. Infiltration of the primary tumor by eosinophils was found to have a marked prognostic significance. Five years after the resection of tumor in the patients with gastric cancer, 29 of 51 patients (56.0%) who showed previously the infiltration of more than 100 eosinophils in tumor tissue were alive, while only 38.6% (61/158) of the patients with the infiltration of less than 100 eosinophils survived (P less than 0.05). Eosinophil infiltration in the resected tumor was detected in 157 patients (24%). The intensive degree of infiltration correlates well with a special pathologic type of cancer, poorly differentiated adenocarcinoma, the size of tumor mass and preoperative blood eosinophilia. The extract from tumors with the marked eosinophilic infiltration was highly chemotactic for eosinophils in vitro. The eosinophil chemotactic activity was found to be heat-labile and nondialyzable. It was therefore considered most likely that eosinophil infiltration in the tumor and blood eosinophilia observed in some patients with gastric cancer were caused by an eosinophil chemotactic factor of gastric cancer and the good indication of the prolonged survival of the patients.

To examine the clinical efficacy and the mechanism of action of polysaccharide K (PSK), a protein-bound polysaccharide extracted from a Basidiomycetes fungus, a randomized double-blind trial was performed by administering PSK to 56 patients and a placebo to another group of 55 patients after surgical operations on their colorectal cancers. The rate of patients in remission (or disease-free) was significantly higher in the PSK group than in the placebo group; the difference between both groups was statistically significant at P less than 0.05 by the log-rank test. The survival rate of patients was also significantly (P less than 0.05) higher in the PSK group than in the control group. The most significant laboratory finding was that polymorphonuclear leukocytes from PSK-treated patients showed remarkable enhancement in their activities, such as random and/or chemotactic locomotion, and phagocytic activity, when compared with those in the control group. In conclusion, PSK was useful as a maintenance therapy for patients after their curative surgical operations for colorectal cancer. The beneficial effects were probably due to the activation of leukocyte functions as one of the many biological-response-modifying (activities induced by PSK).

No abstract

These results indicate that the band length and the band length ratio might be predictive for the progression of collapse in SIF.

Both acetabular head index and band length ratio are important prognostic factors in the care of patients with subchondral insufficiency fractures of the femoral head.

The ONFH patients showed a relatively bone formative condition before the osteoarthritic stage and maintained a higher rate of cartilage turnover throughout several stages compared with the RDA and DDH patients. RDA patients were characterized by a significantly high osteoclast activity.

Advanced solid tumors are exposed to hypoxic conditions over longer periods of time as they grow. Tumor hypoxia is a major factor that induces malignant progression, but most previous studies on tumor hypoxia were performed under short‐term hypoxia for up to 72 hours and few studies have focused on tumor response to chronic hypoxic conditions. Here we show a molecular mechanism by which chronic hypoxia promotes invasive behavior in prostate cancer cells. We found that an epithelial‐mesenchymal transition (EMT)‐driving transcription factor, slug, is specifically upregulated under chronic hypoxia and promotes tumor cell migration and invasion. Unexpectedly, processes associated with EMT, such as loss of E‐cadherin, are not observed under chronic hypoxia. Instead, expression of ephrin‐B1, a ligand of Eph‐related receptor tyrosine kinases, is markedly induced by slug through E‐box motifs and promotes cell migration and invasion. Furthermore, slug and ephrin‐B1 are highly coexpressed in chronic hypoxic cells of human prostate adenocarcinoma tissues after androgen deprivation, which is known to cause tumor hypoxia. Taken together, these results indicate that chronic hypoxia‐induced slug promotes invasive behavior of prostate cancer cells by activating the expression of ephrin‐B1. In addition, ephrin‐B1 may be a novel therapeutic target in combination with androgen deprivation therapy for aggressive prostate cancer.