Isolation of a series of antibiotics produced by a new variety of Streptomyces viridochromogenes was attempted, and three main components were obtained as amorphouspowders. They were primarily active against Grampositive bacteria, anaerobic bacteria and mycoplasmaand characterized as new members of sulfur-containing peptidic antibiotics. The antibiotic complex was named sulfomycin.
The potency and effectiveness of an anti-bacterial catheter coated with a mixture of silver citrate, soybean lecithin and liquid silicon at the ratio of 2:2:8 were compared with those of commercially available anti-bacterial and conventional urethral catheters. This new anti-bacterial catheter showed a strong activity and excellent durability in ordinary in vitro experimental studies. In the present series we have developed new in vitro experimental models for the evaluation of anti-bacterial catheters in inhibiting bacterial ascent via intraluminal or extraluminal route. The characteristic features of the silver citrate/lecithin catheter, namely strong activity and excellent durability, were confirmed using these new models that mimic urinary catheter-associated clinical infections.
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