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It was possible to demonstrate significant reductions of serum triglyceride in patients with gout by reducing either their alcohol intake or body weight. Reduction of serum uric acid by probenecid had no effect on serum triglyceride or cholesterol. Similarly, allopurinol had no significant effect on serum triglycetide, but a significant fall of serum cholesterol was observed.

De novo intracerebral arteriovenous malformations (AVMs) are exceedingly rare with only seven reported cases in the literature. Although generally considered congenital by nature, the lesions do not manifest themselves clinically until the third or fourth decades of life. However, with the advent of improved imaging modalities and more frequent surveillance, an increasing number of de novo cases are being found challenging the concept AVMs develop in the perinatal/antenatal period. Alternatively, this phenomenon could represent a distinct entity in which lesion development occurs after birth. A PubMed search of "de novo cerebral arteriovenous malformation" was performed in which seven reported cases were found. The mean age at diagnosis was 14.7 years with a mean follow-up imaging study of 5.8 years. Lesion location was supratentorial in all previously described cases. This case involves an 18-year-old male with congenital hydrocephalus and seizures diagnosed at 7 months of age. The patient underwent a ventriculoperitoneal shunt and was followed frequently by a neurologist. The last diagnostic imaging was an unremarkable MRI of the brain at age 12. Seven years later, the patient presented with an intracerebral hemorrhage. A CT angiogram demonstrated a large brainstem AVM with an intraparenchymal hemorrhage and intraventricular extension. This case is unique in that it is the first infratentorial de novo AVM. The congenital nature of AVMs is challenged with the increasingly described series of patients with previously documented normal radiographic imaging. This suggests there may be a subset of patients genetically predisposed to postnatal development of AVMs.

SUMMARY Fasting plasma total cholesterol and triglyceride concentrations and high-density lipoprotein (HDL)-cholesterol concentrations have been measured in a random sample of 502 men and 503 women London local government employees, aged 16 to 64 years. In subjects aged 35 to 54 years, the frequency of 'hypercholesterolaemia', defined by one recently recommended criterion of plasma cholesterol .7-1 mmol/l, was 28-0 per cent in the men and 30 4 per cent in the women. The frequency of 'hypertriglyceridaemia' (plasma triglyceride >2-0 mmol/l) in the same age group was 24 8 per cent for the men and 6-0 per cent for the women.In the whole sample of 1005, there was no case of the WHO Type III lipoprotein abnormality and oniy one example of the WHO Type V abnormality. The method of spline function analysis showed unimodality in the two-dimensional cholesterol/triglyceride frequency distribution for both men and women. Using multiple regression analysis, total cholesterol was independently, positively related to log1o-triglyceride, HDL-cholesterol, and age. Log1o-triglyceride was related positively to total cholesterol, body mass index, systolic blood pressure, uric acid, and fasting blood sugar in both sexes.Mean HDL-cholesterol concentrations were significantly higher in women compared with men only in the 45 to 64 age range. By multiple regression analysis, HDL-cholesterol was independently positively related to total cholesterol and negatively related to loglo-triglyceride in both sexes, and positively related to age in women.