Mechanism and treatment of hypertriglyceridaemia in gout.

Gibson, T.; Kilbourn, Kent J.; Horner, I; Simmonds, H. Anne

doi:10.1136/ard.38.1.31

Cited by 38 publications

(17 citation statements)

References 36 publications

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“…A study suggested that higher intracellular uric acid levels could induce mitochondrial translocation of the nicotinamide adenine dinucleotide phosphate oxidase subunit, the nicotinamide adenine dinucleotide phosphate oxidase 4, further leading to increased mitochondrial oxidative stress, mitochondrial dysfunction and citrate to release to the cytosol, ultimately promoting to the synthesis of lipid and TG [42]. Besides, animal experiments showed that the activity of lipase in high SUA levels group was lower than that in low SUA levels group [43]. Increased SUA levels may inhibit the decomposition of serum TG by reducing the activity of enzymes that catalyze the decomposition of TG, leading to a higher incidence of hypertriglyceridaemia in participants with high SUA levels [12].…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid and risk of incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese: a 4-year prospective cohort study

Tian

Zheng

et al. 2020

Annals of Medicine

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Purpose: The aim was to investigate whether serum uric acid (SUA) was associated with incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese. Methods: This prospective cohort study used data from the China Health and Retirement Longitudinal Study. A total of 6,063 participants were included, who were free of hypercholesterolaemia and hypertriglyceridaemia at baseline (2011) and were followed until 2015. Natural cubic spline models were conducted to investigate the dose-response association of SUA with incident hypercholesterolaemia and hypertriglyceridaemia. Moreover, SUA was categorized into four groups according to gender-specific quartiles. Log-binomial regression was performed to explore the association of SUA with hypercholesterolaemia and hypertriglyceridaemia, with the quartile 1 as a reference. Results: After full adjustment, we observed a positive linear dose-response relationship between SUA and hypercholesterolaemia and hypertriglyceridaemia. Compared with the quartile 1 of SUA, the adjusted risk ratios (95% confidence interval) of hypertriglyceridaemia were 1.15 (0.95-1.39), 1.23 (1.02-1.49) and 1.31 (1.08-1.59) for quartile 2-4 (p-value for trend ¼ .004), respectively. Whereas, we failed to find SUA significantly associated with hypercholesterolaemia. Sex-stratified analyses indicated that the association of SUA with hypertriglyceridaemia was more evident in the female. Conclusions: These findings suggest that SUA may be positively associated with incident hypertriglyceridaemia. KEY MESSAGES The natural cubic spline model showed a positive linear dose-response relationship between serum uric acid levels and hypertriglyceridaemia. Compared with the quartile 1 of SUA, the adjusted risk ratios (95% confidence interval) of hypertriglyceridaemia were 1.15 (0.95-1.39), 1.23 (1.02-1.49) and 1.31 (1.08-1.59) for quartile 2-4 (p-value for trend ¼ .004), respectively. Sex-stratified analyses indicated that the association of serum uric acid with hypertriglyceridaemia was more evident in the female.

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Section: Discussionmentioning

confidence: 99%

Serum uric acid and risk of incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese: a 4-year prospective cohort study

Tian

Zheng

et al. 2020

Annals of Medicine

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“…That such a search revealed relatively so little suggests that the association between the hyperuricaemia and hypertriglyceridaemia is not predominantly genetic. Of the other factors that might contribute, the two obvious ones are obesity and alcohol consumption,10 and there is good evidence that each of these, in appropriate individuals, can and does contribute to both hypertriglyceridaemia and hyperuricaemia. Obesity, especially abdominal obesity,11 12 and excessive weight gain in young adulthood,13 have been associated with an increase in both the urate and triglyceride concentrations.…”

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confidence: 99%

Hyperlipidaemia in hyperuricaemia and gout

Emmerson

1998

Annals of the Rheumatic Diseases

116

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“…In 11 obese patients with gout, a mean weight loss of 5 kg resulted in a mean SUA level reduction of 0.06 mmol/L. 32 In 13 obese patients with gout, a mean weight loss of 7.7 kg resulted in a substantial SUA reduction of 0.1 mmol/L. 23 In the study of 12,379 men with high cardiovascular risk observed over a 7-year period, the effect of weight gain of ⩾10 kg on achieving normouricemia increased by approximately 4-fold.…”

Section: Discussionmentioning

confidence: 97%

How much does fat mass change affect serum uric acid levels among apparently clinically healthy Korean men?

Ahn

Hwang

Lee

et al. 2021

Therapeutic Advances in Musculoskeletal

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Objective: The aim of this study was to examine the impact of fat mass alteration on serum uric acid (SUA) levels in apparently clinically healthy men. Methods: We evaluated 27,387 men who consecutively underwent health check ups between 2015 and 2017. We assessed the likelihood of achieving a SUA level of <0.41 mmol/L and compared the SUA levels according to fat mass changes. Results: Compared with those without fat mass change (the reference group), the odds ratios (95% confidence interval) of achieving a SUA level of <0.41 mmol/L for fat mass decreases of ⩾2.5, 1.5–2.5, and 0.5–1.5 kg were 1.63 (1.45–1.82), 1.19 (1.06–1.34), and 1.07 (0.97–1.18), respectively, while those for a fat mass increase of ⩾2.5, 1.5–2.5, and 0.5–1.5 kg were 0.71 (0.64–0.78), 0.87 (0.79–0.97), and 0.95 (0.86–1.04), respectively. The corresponding beta-coefficients of SUA levels (mmol/L) were –0.26 [–0.29–(–0.23)], –0.12 [–0.16–(–0.09)], and –0.09 [–0.12–(–0.06)] for fat mass decreases of ⩾2.5, 1.5–2.5, and 0.5–1.5 kg, respectively. Every 1-kg fat mass reduction was associated with 9% increased odds of achieving the target SUA level. The multivariate SUA level difference per 1-kg fat mass gain was 2.97 µmol/L. Similar levels of association persisted among the prespecified subgroups. Conclusion: We quantitatively demonstrated that fat mass reduction contributes to a clinically relevant decrease in SUA levels and a significant increase in the likelihood of achieving target SUA levels. Our findings may help to provide clear clinical guidance on fat mass alteration to reduce SUA levels in patients with hyperuricemia.

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Mechanism and treatment of hypertriglyceridaemia in gout.

Cited by 38 publications

References 36 publications

Serum uric acid and risk of incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese: a 4-year prospective cohort study

Serum uric acid and risk of incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese: a 4-year prospective cohort study

Hyperlipidaemia in hyperuricaemia and gout

How much does fat mass change affect serum uric acid levels among apparently clinically healthy Korean men?

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