We determined the relationship between the histopathological findings of the placental bed and Doppler flow measurements of the uterine artery in women with preeclampsia and fetal growth retardation. Doppler velocimetry in the uterine artery was evaluated in 17 pregnant women with preeclampsia, 15 of whom had fetal growth retardation, and 20 normal pregnant women, within 14 days of Caesarean delivery and placental bed biopsy. The placental bed biopsies were evaluated in terms of trophoblast migration into the myometrium and physiological changes of the spiral arteries. The results were compared with Doppler velocimetry values. Trophoblast migration and physiological changes were not detected in 10 (59%) cases with preeclampsia and in 4 (20%) with normal pregnancies (p<0.05). In the preeclamptic group, 9 of 15 cases that were complicated with intrauterine growth retardation had no trophoblastic migration into the myometrium. The mean systolic/diastolic ratio, resistance index and pulsatility index of the uterine artery in women with preeclampsia and fetal growth retardation was significantly higher than women with normal pregnancies (p<0.01). The mean resistance index of the uterine artery in the impaired migration group was significantly higher than the migration group (p=0.02). The incidence of impaired trophoblast migration was significantly higher in the group with a high systolic/diastolic ratio (above 2.5) and resistance index (above 0.58) than cases with low systolic/diastolic ratio and resistance index (72%, 23% respectively, p<0.05). The incidence of early diastolic notch in the impaired trophoblast migration group was significantly higher than the migration group (57% versus 13%, p<0.01). Our study supports the hypothesis that high uterine artery flow resistance is related to the reduced trophoblast migration into the myometrium and inadequate physiological changes in the spiral arteries in women with intrauterine growth retardation and preeclampsia.

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The aim of the present study is to determine the fluoride concentrations of breast milk, several milk formulations, cow's milk and yogurt shake in a nonfluoridated area, in order to estimate the fluoride intake of infants and evaluate fluoride supplementation suggestions. Breast milk samples were collected from 57 lactating mothers. Ten brands of milk formulations, 9 different brands of cow's milk and 3 brands of yogurt shake were purchased from the market. Fluoride concentrations of the samples were analyzed using a specific fluoride electrode. The average fluoride level was 0.019±0.004 ppm in breast milk, 0.022±0.007 ppm in cow's milk and 0.022±0.003ppm in yogurt shake. Fluoride levels of milk formulations prepared by distilled water were ranging between 0.118 to 0.021 ppm. It is concluded that in non-fluoridated areas, fluoride intake of infants from the above sources is not very high and fluoride supplements may be prescribed.

This study shows that early onset of menopause is correlated with smoking, employment status, divorced marital status and lower leptin levels.