Comparison of the reduction of postoperative adhesions by two barriers, one solution, and two pharmacologic agents in the rat uterine model

Evaluation of the effects of gonadotropin-relasing hormone antagonist (GnRH-ant) and agonist (GnRH-a) in the prevention of postoperative adhesion formation in a rat model with immunohistochemical analysis

“…When compared with GnRH-a, the preventive effect on the extent of adhesions was found to be less, but this difference was not significant. In accordance with this study, many animal and some human studies have demonstrated that GnRH-a decreases pelvic adhesions (8,10,12,15,(24)(25)(26). Ustun et al have compared the effects of GnRH-a with medroxyprogesterone acetate (MPA) and Ringer's lactate and have found a significant decrease in postoperative adhesions when GnRH-a was used (8).…”

A Sprayable Hyaluronate/Carboxymethylcellulose Adhesion Barrier Exhibits Regional Adhesion Reduction Efficacy and Does Not Impair Intestinal Healing

“…Additionally, the transudation of a serosanguineous fluid within hours of peritoneal trauma may further contribute to the physical change from a powder to a gelatinous viscous coating on the injured mesothelial layer acting as a regional barrier to adhesion formation. 22,23 A similar principle of "hydroflotation" and "siliconizing" has been described for other instillates by Diamond et al 23,24 Bioabsorbable gels and solutions have the theoretical advantage of a wider area of peritoneal distribution and thus greater efficacy as a means to prevent adhesiogenesis. However, there are concerns as to their ability to be retained in the highly absorptive environment of the abdomen during the critical period of adhesion formation, as well as concerns regarding both septic complications and the perceived ability to act as a nidus for abscess formation.…”

Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats

“…As compared to results recently published in the literature using Adept® (Baxter Healthcare Corporation, USA) [28,29,30,31,32,33], Interceed® (Ethicon, Inc., USA) [25,27,29,34,35,36,37,38,39], and Seprafilm® (Genzyme Corporation, USA) [26,27,31,34,38,39,40,41,42,43,44] in rat models, the results obtained with 4DryField PH in this study are in the upper range of benefit and are comparable with the data of Kaptanoglu et al [43] and Wallwiener et al [29]. …”