Evaluation of the effects of gonadotropin-relasing hormone antagonist (GnRH-ant) and agonist (GnRH-a) in the prevention of postoperative adhesion formation in a rat model with immunohistochemical analysis

Evaluation of the effects of fulvestrant and micronized progesterone on the post-operative adhesion formation and ovarian reserve in rat model with immunohistochemical and biochemical analysis

“…Estrogen also regulates angiogenesis and regulation of mesothelial cell proliferation. Therefore, many animal studies have demonstrated that anti-estrogenic agents decreased adhesion formation [6][7][8][35][36][37][38]. In the current study, fulvestrant and micronized progesterone antagonized all these pathways and contributed to the prevention of adhesion formation by creating a hypoestrogenic milieu.…”

“…Estrogen also may modulate the expression of vascular endothelial growth factor and basic fibroblast growth factor which leads to expansion of capillary perfusion of adhesion [6]. Hypoestrogenic milieu was found to reduce estrogen dependent angiogenic growth factors, epidermal growth factor and platelet derived growth factor caused fibrovascular bands [7]. Therefore, anti-estrogenic drugs may have anti-inflammatory effects which may make their usage possible in the prevention of post-operative adhesion formation [6][7][8].…”

“…Hypoestrogenic milieu was found to reduce estrogen dependent angiogenic growth factors, epidermal growth factor and platelet derived growth factor caused fibrovascular bands [7]. Therefore, anti-estrogenic drugs may have anti-inflammatory effects which may make their usage possible in the prevention of post-operative adhesion formation [6][7][8]. Fulvestrant, which works as a selective estrogen receptor down-regulator (SERD) is an estrogen receptor antagonist [9].…”

Lipoic acid decreases peritoneal adhesion formation in a rat uterine scar model

“…Similarly, after a myomectomy there is a risk of peritoneal adhesion formation. There are several experimental models for producing peritoneal adhesions in laboratory animals; the damaged uterine horn model by electrocautary or scraping, caecal abrasion, peritonitis model and the bowel anastomosis model (4,(17)(18)(19)(20). Tissue remodelling markers were used to verify the results.…”

“…The authors have contributed to the literature on adhesion evaluation via an immunohistochemical method using u-PAR and vitronectin markers for objective evaluation (4). The authors have contributed to the literature on adhesion evaluation via an immunohistochemical method using u-PAR and vitronectin markers for objective evaluation (4).…”