Lipoic acid decreases peritoneal adhesion formation in a rat uterine scar model

Mıçılı, Serap Cilaker; Göker, Aslı; Sayın, Oya; Akokay, Pınar; Ergür, Bekir Uğur

doi:10.5152/jtgga.2013.22129

Cited by 4 publications

(1 citation statement)

References 26 publications

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“… 11 Rats were randomly assigned to 3 equal groups, each consisting of 7 rats similar to previous models. 12 , 13 Before closure of the abdomen, rats in the control group were administered intraperitoneally with 3 mL of 0.9% sodium chloride solution. 14 In group 2, traumatized areas on the uterine horns were covered by a single layer of 2 × 2 cm HA/CMC films before closure.…”

Section: Methodsmentioning

confidence: 99%

Tranexamic Acid and Hyaluronate/Carboxymethylcellulose Create Cell Injury

Yildiz

Yılmaz

Dilbaz

et al. 2014

JSLS

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Background and Objectives:Postoperative pelvic adhesions are associated with chronic pelvic pain, dyspareunia, and infertility. The aim of this study was to evaluate the adhesion prevention effects of tranexamic acid (TA) and hyaluronate/carboxymethylcellulose (HA/CMC) barrier in the rat uterine horn models on the basis of macroscopic and microscopic adhesion scores and histopathological as well as biochemical parameters of inflammation.Methods:Twenty-one Wistar rats were randomly divided into 3 groups. Ten lesions were created on the antimesenteric surface of both uterine horns by bipolar cautery. Three milliliters of 0.9% sodium chloride solution were administered in the control group. A single layer of 2 × 2 cm HA/CMC was plated in group 2. Two milliliters of TA was applied in the last group. All rats were sacrificed at postoperative day 21.Results:No significant difference was found among the control group, the HA/CMC group, and the TA group in terms of macro-adhesion score (P = .206) and microadhesion score (P = .056). No significant difference was found among the 3 groups in terms of inflammation score (P = .815) and inflammatory cell activity (P = .835). Malondialdehyde levels were significantly lower in the control group than in the TA group and HA/CMC group (P = .028). Superoxide dismutase and glutathione S-transferase activities were found to be higher in the control group than in the TA group (P = .005) and HA/CMC group (P = .009).Conclusions:TA and HA/CMC had no efficacy in preventing macroscopic or microscopic adhesion formation and decreasing inflammatory cell activity or inflammation score in our rat models. TA and HA/CMC increased the levels of free radicals and reduced the activities of superoxide dismutase and glutathione S-transferase enzymes, which act to reduce tissue injury.

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