The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial

Sammour, Hazem; Elkholy, Abdellatif; Rasheedy, Radwa; Fadel, Ebtesam

doi:10.1007/s00404-018-5011-2

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…The higher prevalence of CSD in our study (82.2% of women in both groups) came in agreement with previous studies that reported prevalence up to 88% with the use of SCSH [10,18,26,34,35]. This high prevalence may be due to the use of SCSH and not the un-enhanced ultrasound during the assessment or may be due to performing CS in all participants by intermediate registrars or using of braided sutures (they were the only type of sutures available in both hospitals) for uterine closure.…”

Section: Discussionsupporting

confidence: 93%

“…Many studies were performed to evaluate risk factors, etiologies, and different methods to treat CSD. The therapeutic interventions targeting CSD increases the medical consultations and related costs, thus; it seems more efficient to prevent CSD development in the first place, thus identification of the related risk factors is of paramount importance [10,21,22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Several clinical and non-clinical interventions have been proposed by WHO aiming to reduce unnecessary CD [9] and hence, the complications attributed to CSD. This aim could be achieved by maintaining the uterine integrity through optimal cesarean wound healing [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between Urgency of Cesarean birth and Cesarean Scar Defects: prospective study

Elhodiby¹,

Tamara²,

Elkoumy³

et al. 2023

Ital J Gynaecol Obstet

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Urgency of Cesarean birth and Cesarean Scar Defects: prospective study

Elhodiby¹,

Tamara²,

Elkoumy³

et al. 2023

Ital J Gynaecol Obstet

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“…ALA reduces chemotherapy side effects having a substantial role in potentiating and synergizing the cytotoxic effect of antineoplastic agents while protecting normal body tissue, increasing patient survivability [53]. ALA's anti-proliferative effect on tumor cells is due to the increased reduction in epidermal growth factor receptor expression ErbB2 and ErbB3 [54].…”

Section: Ala and Cancermentioning

confidence: 99%

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Pop

Crișan²,

Barca

et al. 2021

Processes

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Alpha-lipoic acid (ALA, thioctic acid), a naturally-occurring essential dithiol compound, has become a common ingredient in many pharmaceutical and food supplement products (FSP), used in oxidative stress-dependent pathologies; oral bioavailability of ALA is limited by pharmacokinetic particularities that reduce its therapeutic efficacy-reduced solubility, lack of gastric stability and hepatic degradation, doubled by formulation hinders. The objectives were to develop a solid oral 600 mg ALA FSP to obtain an optimal pharmaceutical profile compared to a reference listed drug (RLD) with a similarity factor f2 50. A comparative dissolution study was performed; an HPLC method was used for ALA quantification. After planning combinatory simulations (formulation stage), two prototype formulas (#1 and #2) were manufactured and further optimized by adjusting ALA physical characteristics and the excipients quantities (#3 and #4) in order to achieve the Quality Target Product Profile. A misshapen of ALA’s in vitro release was observed for #3 Formula (f2 = 31.6); the optimal profile was obtained for Formula #4 (f2 = 58.5). A simple quantitative formula is not enough to assure good ALA bioavailability; the formulation needs multiple compounding modulations under physicochemical compatibility algorithms, with multiple dissolution profiles testing back-ups. It is essential to ensure a formulation with an in vitro dissolution comparable with the RLD, allowing the compound to reach its target level to assure the optimum claimed antioxidant activity of ALA at the cellular level, even for food supplement formulations.

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“…Existing studies showed that ALA could accelerate mouse cutaneous wound healing [ 23 ] or promote human postoperative uterine healing [ 24 ]. However, its effect on intestinal epithelial wound healing remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways

Xiao

Jiang

et al. 2022

Mediators of Inflammation

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Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injury repair. The effects of ALA in human colonic epithelial cells NCM460 and human colorectal adenocarcinoma cells Caco-2 were studied. ALA significantly promoted NCM460 and Caco-2 migration, increased mucosal tight junction factors ZO-1 and OCLN expression, and ALA accelerated cell injury repair of both cells in wound healing assay. Western blot analysis indicated that ALA inhibited a variety of mitogen-activated protein kinase (MAPK) signaling pathways in the epithelial cells. In conclusion, ALA was beneficial to repair of intestinal epithelial injury by regulating MAPK signaling pathways.

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The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial

Cited by 10 publications

References 26 publications

Association between Urgency of Cesarean birth and Cesarean Scar Defects: prospective study

Association between Urgency of Cesarean birth and Cesarean Scar Defects: prospective study

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways

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