IMPORTANCE Case-based surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection likely underestimates the true prevalence of infections. Large-scale seroprevalence surveys can better estimate infection across many geographic regions. OBJECTIVE To estimate the prevalence of persons with SARS-CoV-2 antibodies using residual sera from commercial laboratories across the US and assess changes over time. DESIGN, SETTING, AND PARTICIPANTS This repeated, cross-sectional study conducted across all 50 states, the District of Columbia, and Puerto Rico used a convenience sample of residual serum specimens provided by persons of all ages that were originally submitted for routine screening or clinical management from 2 private clinical commercial laboratories. Samples were obtained during 4 collection periods

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Background Engaging diverse populations in biomedical research, including biospecimen donation, remains a national challenge. This study examined factors associated with an invitation to participate in biomedical research, intent to participate in biomedical research in the future, and participation in biomedical research and biospecimen donation among a diverse, multilingual, community‐based sample across 3 distinct geographic areas. Methods Three National Cancer Institute–designated cancer centers engaged in community partnerships to develop and implement population health assessments, reaching a convenience sample of 4343 participants spanning their respective catchment areas. Data harmonization, multiple imputation, and multivariable logistic modeling were used. Results African Americans, Hispanic/Latinos, and other racial minority groups were more likely to be offered opportunities to participate in biomedical research compared to whites. Access to care, history of cancer, educational level, survey language, nativity, and rural residence also influenced opportunity, intent, and actual participation in biomedical research. Conclusions Traditionally underserved racial and ethnic groups reported heightened opportunity and interest in participating in biomedical research. Well‐established community partnerships and long‐standing community engagement around biomedical research led to a diverse sample being reached at each site and may in part explain the current study findings. However, this study illustrates an ongoing need to establish trust and diversify biomedical research participation through innovative and tailored approaches. National Cancer Institute–designated cancer centers have the potential to increase opportunities for diverse participation in biomedical research through community partnerships and engagement. Additional work remains to identify and address system‐level and individual‐level barriers to participation in both clinical trials and biospecimen donation for research.

Purpose The purpose of this study was to investigate the relationship between social support (from personal and workplace sources) and psychological distress (depression, anxiety, and stress symptoms), as well as to examine the mediating role of satisfaction with work–family balance among hospice nurses. Design and Method A cross‐sectional study design was utilized with a sample of 90 hospice nurses from the southern United States. Participants completed online surveys, including (a) the Depression, Anxiety, and Stress Scale (DASS‐21), (b) loosely adapted items from the Affectivity, Burnout, and Absenteeism Scales, and (c) Satisfaction with Work–Family Balance Scale. Findings Workplace social support, not personal social support, was associated with lower psychological distress, and satisfaction with work–family balance mediated the relationship between workplace social support and depression symptoms, a component of psychological distress. Conclusions Hospice nurses’ social support in the workplace and their satisfaction with the balance between their work and family lives play a role in supporting their mental health. Clinical Relevance Hospice nurses may benefit from programs fostering the creation of workplace‐based interpersonal relationships.

Growing interest in the anaerobic treatment of domestic wastewater requires a parallel focus on developing downstream technologies that address nitrogen pollution, especially for treatment systems located in eutrophication-impacted watersheds. Anaerobic effluents contain sulfide and hydrogen sulfide (a corrosive gas), dissolved methane (a potent greenhouse gas), ammonium, and residual organic carbon predominantly in the form of volatile fatty acids. Conventional approaches to nitrogen removal are energyand chemical-intensive and are not appropriate for application to anaerobic effluents. Innovative, energy efficient nitrogen removal processes are being developed and involve several novel chemotrophic processes. This review provides information about these processes, identifies how to control and retain the most desirable microorganisms, and considers the impact of reactor configuration on performance. Given the complexity of the technologies under development that remove nitrogen from anaerobically treated domestic wastewater, we conclude that computational models can support their development and that sensor-mediated controls are essential to achieving energy efficiency.