CONTEXT AND OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a cyclical clinical course. Evaluation of the clinical activity of this disease is important for choosing the correct treatment. The objective of this study was to analyze the value of beta-2 microglobulin (β2M) serum levels in determining SLE clinical activity. DESIGN AND SETTING: Cross-sectional analytical study conducted at the rheumatology outpatient clinic of a private university hospital. METHODS: 129 SLE patients were studied regarding disease activity using SLEDAI (SLE Disease Activity Index) and cumulative damage using SLICC ACR (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). At the same time, the β2M serum level, ESR (erythrocyte sedimentation rate), anti-dsDNA (anti-double-stranded DNA) and C3 and C4 complement fractions were determined. RESULTS: β2M levels correlated positively with SLEDAI (P = 0.02) and ESR (P = 0.0009) and negatively with C3 (P = 0.007). Patients who were positive for anti-dsDNA had higher β2M serum levels (P = 0.009). CONCLUSION: β2M levels are elevated in SLE patients with active disease.RESUMO CONTEXTO E OBJETIVO: O lúpus eritematoso sistêmico (LES) é uma doença autoimune com curso clí-nico flutuante. Determinar a atividade clínica da doença é importante na escolha do tratamento correto. O objetivo deste estudo foi o de analisar se os níveis séricos de beta-2 microglobulina (β2M) têm valor na determinação da atividade clínica do LES. TIPO DE ESTUDO E LOCAL: Estudo transversal, analítico, realizado no ambulatório de reumatologia de um hospital universitário particular. MÉTODOS: 129 pacientes com LES foram estudados para atividade da doença pelo SLEDAI (SLE Disease Activity Index) e para dano cumulativo pelo SLICC (SLE International Collaborating Clinics/American College of Rheumatology Damage Index for SLE). Simultaneamente foram determinados os valores séricos de β2M, das frações C3 e C4 do complemento, VHS (velocidade de hemossedimentação) e anti dsDNA (DNA de dupla fita). RESULTADO: Encontrou-se correlação positiva entre níveis de β2M com o SLEDAI (P = 0,02), com VHS (P = 0,0009) e correlação negativa com níveis de C3 (P = 0,007). Pacientes com presença de anti dsDNA tinham níveis mais altos de β2M (P = 0,009). CONCLUSÃO: Níveis de β2M estão elevados em pacientes de LES com doença ativa.
CT CT CT CT findings in patients submitted to findings in patients submitted to findings in patients submitted to findings in patients submitted to findings in patients submitted to Roux-en-y gastric bypass without ring Roux-en-y gastric bypass without ring Roux-en-y gastric bypass without ring Roux-en-y gastric bypass without ring Roux-en-y gastric bypass without ring Achados tomográficos das alterações abdominais pós-operatórias dos pacientes Achados tomográficos das alterações abdominais pós-operatórias dos pacientes Achados tomográficos das alterações abdominais pós-operatórias dos pacientes Achados tomográficos das alterações abdominais pós-operatórias dos pacientes Achados tomográficos das alterações abdominais pós-operatórias dos pacientes submetidos ao derivação gastrojejunal em Y-de-Roux sem anel submetidos ao derivação gastrojejunal em Y-de-Roux sem anel submetidos ao derivação gastrojejunal em Y-de-Roux sem anel submetidos ao derivação gastrojejunal em Y-de-Roux sem anel submetidos ao derivação gastrojejunal em Y-de-Roux sem anel FERNANDA We studied 40 CT exams from patients attended at the radiology service with the intention to clarify abdominal complains. The patients were in post-bariatric surgical follow-up and were operated in the same hospital. We excluded patients who had undergone bariatric surgery by other surgical techniques, operated by another surgical team and the ones who did not agree with the administration of oral or intravenous iodinated contrast media and exceeding the weight limit of the examination table. Results Results ResultsResults Results: The patients were aged from 23 to 70 years, 11 male and 29 female. There were no extra-abdominal changes, and 30 of the 40 patients had CT findings within normal limits. The presence of stenosis at the gastrojejunal anastomosis was found in one patient, internal hernias occurred in five, anastomotic leak in one and the presence of abscess occurred in three of patients. ConclusionConclusion Conclusion Conclusion Conclusion: Total abdominal CT failed to inform the cause of the symptoms in 87.5% of patients seeking medical re-evaluation for symptoms of post-operative bariatric surgery. Due to the need for more effective intervention in the clinical management of severe obesity, the indications for bariatric operations have been growing 5 . The surgical treatment for severe obesity has been employed for nearly half a century. It began in the 1950s with operations that caused malabsorption, abandoned in the late 1970s due to their serious side effects. From then on, procedures that limit food intake began to dominate, either by simply restricting the capacity of the stomach, or by its division and anastomosis to the proximal jejunum 6 . Among the surgical techniques currently considered for treatment of morbid obesity, Roux-en-Y gastric bypass is widely used 2,6,7 . With the increase in the frequency of bariatric operations, it is necessary that the radiologist must be aware The postoperative radiological study, the survey of complications an...
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