A retrospective cohort study at four academic medical centers with high COVID-19 vaccination rates evaluated breakthrough SARS-CoV-2 Delta variant (B.1.617.2) infections in vaccinated healthcare workers. Few work-related secondary cases were identified. Breakthrough cases were largely due to unmasked social activities outside of work.
Most health care personnel who tested positive using the asymptomatic testing pathway reported symptoms consistent with ). Asymptomatic cases declined to 0 after vaccination.
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