Asymptomatic and Symptomatic COVID-19 Infections Among Health Care Personnel Before and After Vaccination

Gohil, Shruti K; Olenslager, Keith; Quan, Kathleen A.; Dastur, Cyrus K.; Afsar, Nasim; Chang, W.; Huang, Susan S.

doi:10.1001/jamanetworkopen.2021.15980

Cited by 12 publications

(13 citation statements)

References 4 publications

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“…Nevertheless, COVID-19 infections among HCW had been frequently reported both before and after the vaccine rollout with a clear and sustained decline in cases number after mass vaccination [95]. This finding confirms the substantial pooled effectiveness of the approved vaccines in the Czech Republic and the European Union, and it is in agreement with the previous findings of rapid decline in both asymptomatic and symptomatic COVID-19 infections among HCW following vaccine rollout in California [95,96].…”

Section: Discussionsupporting

confidence: 89%

COVID-19 Vaccine Booster Hesitancy (VBH) of Healthcare Workers in Czechia: National Cross-Sectional Study

et al. 2021

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The emerging SARS-CoV-2 variants and waning vaccine-elicited immunity are two public health challenges that occurred simultaneously and synergistically during the summer of 2021 and led to a surging demand for COVID-19 vaccine booster dose (BD) rollout. This study aimed to evaluate the COVID-19 vaccine booster hesitancy (VBH) among Czech healthcare workers to explore the potential determinants of VBH. A national cross-sectional survey-based study was carried out between 3 and 11 November 2021, using an online self-administered questionnaire (SAQ) that explored the participants’ demographic characteristics, COVID-19 infection and vaccine anamneses, willingness to receive COVID-19 vaccine BD, and the psychosocial drivers of VBH. A total of 3454 HCW properly responded to the online SAQ, of which 80.9% were females, 30.3% were medical professionals, and 50.5% were ≤47 years old. Most of the participants were already inoculated against SARS-CoV-2 (95.2%), and BTN162b2 was the most commonly administered vaccine (90.7%). As the study sample was planned to represent the target population, it revealed a high level of BD acceptance (71.3%) among Czech HCW, while 12.2% were still hesitant and 16.6% were against the currently available BD. These results are consistent with other recent results from central Europe. Medical professional, male, and older participants were more likely to accept BD rather than allied health professional, female, and younger participants. The BDs’ perceived effectiveness against severe illness, symptomatic infection, and community transmission was a significant and strong predictor for BD acceptance, while the effectiveness against the circulating variants was not that important for our target population. The BDs’ perceived safety and ethical dilemmas of vaccine justice should be addressed sufficiently while communicating with HCW and other population groups. The altruistic reasons for BD acceptance, i.e., family protection, patient protection, and community health protection, underpin the recommendation of postponing the COVID-19 vaccine mandating in favour of stressing these altruistic concerns amid public health messaging.

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Section: Discussionsupporting

confidence: 89%

COVID-19 Vaccine Booster Hesitancy (VBH) of Healthcare Workers in Czechia: National Cross-Sectional Study

et al. 2021

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“…We confirm real world effectiveness of BNT162b2 vaccines in the adult Japanese population, consistent with findings from other non-Asian countries. 3,4 Nonetheless, breakthrough cases with highly transmissible variants, even in institutions with strict safety and hygiene protocols, suggest that appropriate measures will continue to be required even after vaccination.…”

Section: Dear Editormentioning

confidence: 99%

Real-world evidence for the effectiveness and breakthrough of BNT162b2 mRNA COVID-19 vaccine at a medical center in Japan

Naito

Yan

Tabe

et al. 2021

Human Vaccines & Immunotherapeutics

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Evidence of BNT126b2 vaccine effectiveness and breakthrough has been primarily demonstrated in populations outside of Asia; studies in the Western Pacific region are limited. Our retrospective cohort study assessed SARS-CoV-2 cases after vaccine rollout starting from mid-March 2021 at a tertiary hospital in Tokyo. Of 8,749 staff members, no fully vaccinated staff demonstrated confirmed infection, versus 19 cases in unvaccinated or partially vaccinated staff, by the end of June. Three breakthrough cases were identified in July, correlating with spread of delta variant in Tokyo. While our findings confirm the effectiveness of BNT162b2 vaccine in Asian populations, the presence of breakthrough cases despite strict infection control regulations suggest that ongoing public hygiene measures are required even after vaccination.

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“…1 , 2 However, the utility of surveillance testing for LTC HCP who have been vaccinated against COVID-19 is unclear. Although rates of positive results among HCP who are vaccinated are extremely low, 3 , 4 , 5 breakthrough infections and transmission still occur. 6 …”

Section: Introductionmentioning

confidence: 99%

Vaccination Status and the Detection of SARS-CoV-2 Infection in Health Care Personnel Under Surveillance in Long-term Residential Facilities

et al. 2021

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Asymptomatic and Symptomatic COVID-19 Infections Among Health Care Personnel Before and After Vaccination

Abstract: Most health care personnel who tested positive using the asymptomatic testing pathway reported symptoms consistent with ). Asymptomatic cases declined to 0 after vaccination.

Cited by 12 publications

References 4 publications

COVID-19 Vaccine Booster Hesitancy (VBH) of Healthcare Workers in Czechia: National Cross-Sectional Study

COVID-19 Vaccine Booster Hesitancy (VBH) of Healthcare Workers in Czechia: National Cross-Sectional Study

Real-world evidence for the effectiveness and breakthrough of BNT162b2 mRNA COVID-19 vaccine at a medical center in Japan

Vaccination Status and the Detection of SARS-CoV-2 Infection in Health Care Personnel Under Surveillance in Long-term Residential Facilities

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