Introduction: Kidney injury is common in the course of lupus and affects the functional and vital prognosis. The risk of progression to end-stage renal failure can reach 40% to 60%. Thus we carried out this work for the purpose of an evaluation of the renal and vital prognosis and to deduce the factors of poor prognosis. Patients and method: This was a retrospective, descriptive and analytical study conducted over a period of 10 years from January 1, 2007 to December 31, 2016, performed in the Nephrology Department of Aristide Le Dantec Hospital in Dakar. Patients with lupus nephritis were included. The studied parameters were epidemiological, clinical, paraclinical and progression. We had done a crossover of the patients to look for the factors of poor renal and vital prognosis. Results: Out of 93 cases of lupus patients, 64 were included, a prevalence of 69%. The mean age of the patients was 31.97 ± 10.44 years old. There were 81% women and 19% men, a sex ratio of 0.23. Class III was found in 24 cases (37.5%), Class IV in 20 cases (31.25%), Class V in 15 cases (23.4%), Class II in 4 cases (6.25%) and Class I in 1 case (1.6%). The combination of corticosteroids and immunosuppressants was used in 56.25% of cases. After a follow-up of six months, 19 patients were in complete remission, 21 had resistance and 9 had partial remission. Of the 21 patients who had resistance, 8 were in chronic renal failure. Death was observed in 5 patients and the causes were in 3 patients: pulmonary embolism, bacterial meningitis and pulmonary tuberculosis. The cause of death was unknown in 2 patients. The factors of poor renal prognosis were lymphopenia, the presence of anti-native DNA antibodies, nephrotic syndrome, microscopic hematuria, tubular atrophy and interstitial fibrosis. Risk factors affecting renal survival were the presence of native anti-DNA antibodies, microscopic hematuria, leukocyturia and the presence of a proliferative class. The factors of poor prognosis were renal failure, lymphopenia, nephrotic syndrome, glo
Introduction: This study was conducted to look for clinico-histological correlation during lupus nephritis. Patients and method: It was a retrospective and analytical study, conducted over a period of 10 years from 01 January 2007 to 31 December 2016 in the nephrology department of Aristide Le Dantec Hospital in Dakar. Histological parameters were crossed over with demographic, clinical and biological data to search for clinicobiological and histological correlation. Results: In a total of 93 black patients with lupus, 64 were included, giving a hospital prevalence of 69%. The mean age of the patients was 31.97 ± 10.44 years old. There were 81% women and 19% men with a sex ratio of 0.23. The existence of hypertension and renal failure was correlated with the presence of a proliferative class.Interstitial fibrosis was correlated with renal failure. A statistically significant correlation was found between the presence of interstitial infiltration and the existence of renal failure and leukocyturia. Fibrous endarteritis was correlated with renal failure and hypertension. Arteriosclerosis was associated with hypertension. Conclusion: Proliferative classes, interstitial fibrosis, interstitial infiltration and chronic vascular lesions were correlated with severe clinico-biological manifestations. Multicentric studies are needed to support these results.
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