Anatomoclinical Correlation in Black Patients with Lupus Nephritis Living in Senegal

Abstract

Introduction: This study was conducted to look for clinico-histological correlation during lupus nephritis. Patients and method: It was a retrospective and analytical study, conducted over a period of 10 years from 01 January 2007 to 31 December 2016 in the nephrology department of Aristide Le Dantec Hospital in Dakar. Histological parameters were crossed over with demographic, clinical and biological data to search for clinicobiological and histological correlation. Results: In a total of 93 black patients with lupus, 64 were included, giving a hospital prevalence of 69%. The mean age of the patients was 31.97 ± 10.44 years old. There were 81% women and 19% men with a sex ratio of 0.23. The existence of hypertension and renal failure was correlated with the presence of a proliferative class.Interstitial fibrosis was correlated with renal failure. A statistically significant correlation was found between the presence of interstitial infiltration and the existence of renal failure and leukocyturia. Fibrous endarteritis was correlated with renal failure and hypertension. Arteriosclerosis was associated with hypertension. Conclusion: Proliferative classes, interstitial fibrosis, interstitial infiltration and chronic vascular lesions were correlated with severe clinico-biological manifestations. Multicentric studies are needed to support these results.