Prostate cancer and prostatitis are both significant health concerns. A large number of studies have established that the occurrence of the two is closely related. However, the most common prostatitis, type III chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS), is reported to not correlate with the occurrence of prostate cancer. Although the etiology of CP/CPPS is unknown, it may be related to the autoimmune mechanism favored by most studies. Manipulating the immune system and targeting tumor microenvironment are promising new methods for the treatment of prostate cancer. Therefore, this review focuses on the immune cells and cytokines of CP/CPPS and prostate cancer from the perspective of biological immunology and immune microenvironment. We discuss T‐regulatory (Treg) and T helper 17 (Th17) cells dysfunction, the abnormal regulation of T helper 1(Th1) and T helper 2 (Th2) cells, macrophages, and their related cytokines as key activators in CP/CPPS. In addition, we discuss the roles of Treg and Th17 cells, Th1 and Th2 cells, and related cytokines in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines provide a research strategy for the etiology of CP/CPPS and offer potentially promising targets for the treatment of prostate cancer.
An amino poly (styrene-co-maleic anhydride) polymer (ASMA) encapsulated γ-Al 2 O 3 pellet material has been synthesized successfully. After loading with Pd species and modified with morpholine, the inorganic-organic hybrid material shows an excellent catalytic property in the selective hydrogenation of p-chloronitrobenzene (p-CNB) to p-chloroaniline (p-CAN). In this procedure, morpholine can connect with the polymer layer in a form of amide bond and acts as an unparalleled immobilized dechlorination inhibitor, which can avoid further dechlorination efficiently and keeps stability due to the repulsive effect from the surviving C-O-C bond. The catalyst as prepared was characterized by using XRD, TGA, SEM, TEM, FT-IR, and ICP-OES, and it was further tested in the selective hydrogenation of p-CNB. It shows a supreme catalytic activity (almost 100%) and selectivity (up to 99.51%) after recycling for even 10 times, much superior to the blank alumina supported palladium (47.09%).
The
single-metallic coordination networks (CNs), simultaneously
exhibiting temperature-dependent lifetime (TDLT) and emission band
shift (TDEBS), are desirable for application in luminescent thermometers
with high accuracy and reliability in a large temperature range. Nonetheless,
up to date, there are no reports on such kinds of materials due to
the lack of in-depth understanding of the origin of TDLT and TDEBS
at a molecule level, being critical for exploiting a universal approach
to design a dual-parametric CN phosphorescent thermometer (CN-PT).
Herein, we have constructed a thermoresponsive CN [Cu2(L1)Br2]∞ (IAM21-1, L1 = N
1,N
6-di(pyridin-3-yl)adipamide)
via a flexible-ligand-implanted strategy. The TDLT and TDEBS properties
of IAM21-1 enable it to be applied as a single-metallic dual-parametric
CN-PT in 50–500 K, which is the widest temperature range reported
so far. The combination of structure analysis and DFT calculations
demonstrates that the redshift of the emission band upon the decreasing
temperature originates from the reversible skeleton-shrinkage-triggered
narrower band gap. This work has unveiled the origin of TDLT and TDEBS
properties and proposed an efficient strategy for designing dual-parametric
CN-PTs.
Two novel three-dimensional dinitrogen-supported coordination polymers adopting the (53·73)2(54·82) and (53)4(58·64·78·84·94)2-3,8T16 topologies are reported.
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