A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.

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Confocal micro-Raman spectroscopy is employed to characterize various grades of human cataracts. Results show that the intensity ratio of the tyrosine doublet (I855/I833) changes from 1:1.07 ± 0.03 to 1:1.17 ± 0.05 with the aggravation of cataracts, which indicates that there are more tyrosine residues bound to strong H acceptors instead of bounding to water. The decrease of relative intensity at 880 cm−1 band suggests that the “buried” tryptophan residues become “exposed” during the course of lens opacification. A three-dimensional principal component analysis is used to classify the Raman spectra of opacity tissues, which show a one-to-one correspondence with different grades of cataracts.

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