Chiral N-heterocyclic carbenes, which are derived from C2-symmetric 1,3-bis(1-arylethyl)imidazolium salts, catalyze enantioselective acylation of racemic secondary alcohols.
Enantioselective syntheses O 0031First Example of Chiral N-Heterocyclic Carbenes as Catalysts for Kinetic Resolution. -Chiral N-heterocyclic carbenes, which are derived from C2-symmetric 1,3-bis(1-arylethyl)imidazolium salts (I), catalyze the enantioselective acylation of racemic secondary alcohols. -(SUZUKI*, Y.; YAMAUCHI, K.; MURAMATSU, K.; SATO, M.; Chem.
Cyanation O 0273 Cyanosilylation of Aldehydes Catalyzed by N-Heterocyclic Carbenes. -Cyanohydrins (III) are prepared in good yields under the conditions shown. The asymmetric version is performed with optically active imidazolium salt NEI, but only low enantioselectivites are achieved. -(SUZUKI*, Y.; ABU BAKAR, M.; MURAMATSU, K.; SATO, M.; Tetrahedron 62 (2006) 17, 4227-4231; Sch. Pharm. Sci., Univ. Shizuoka,
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