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The advent of microblogging services represented by Twitter evidently stirred a popular trend of personal update sharing from all over the world. Furthermore, the recent mobile device and wireless network technologies are greatly expanding the connectivity between people over the social networking sites. Regarding the shared buzzes over the sites as a crowd-sourced database reflecting a various kind of real-world events, we are able to conduct a variety of social analytics using the crowd power in much easier ways. In this paper, we propose a geo-social event detection method by finding out unusually crowded places based on the conception of social networking sites as a social event detector. In order to detect unusual statuses of a region, we previously construct geographical regularities deduced from geo-tagged microblogs. Especially, we utilize a large number of geo-tagged Twitter messages which are collected by means of our own tweets acquisition method in terms of geographic relevancy. By comparing to those regularities, we decide if there are any unusual events happening in monitoring geographical areas. Finally, we describe the experimental results to evaluate the proposed unusuality detection method on the basis of geographical regularities which are computed from a large number of real geo-tagged tweet dataset around Japan.

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835YAKUGAKU ZASSHI 135(6) 835-840 (2015) It has been reported that magnesium oxide tablets are excreted in a non-disintegrated state in the stool of patients when the tablets are administered after being immersed in a food thickener. Therefore we examined whether immersion in a food thickener aŠects the pharmacological eŠect in patients taking magnesium oxide tablets, and whether immersion aŠects its disintegration and solubility. The mean dosage (1705 mg/d) was higher for patients who took tablets after immersion in a food thickener than for those who took non-immersed tablets (1380 mg/d). The disintegration time and dissolution rate of the immersed tablets were lower than those of non-immersed tablets in vitro. Furthermore, components that constitute the food thickener and diŠerences in composition concentrations diŠerentially aŠect the disintegration and solubility of magnesium oxide tablets. This suggests that commercially available food thickeners are likely to be associated with changes in the degradation of magnesium oxide tablets, and they therefore should be carefully used in certain clinical situations.