Effect of Food Thickener on Disintegration and Dissolution of Magnesium Oxide Tablets

Abstract

835YAKUGAKU ZASSHI 135(6) 835-840 (2015) It has been reported that magnesium oxide tablets are excreted in a non-disintegrated state in the stool of patients when the tablets are administered after being immersed in a food thickener. Therefore we examined whether immersion in a food thickener aŠects the pharmacological eŠect in patients taking magnesium oxide tablets, and whether immersion aŠects its disintegration and solubility. The mean dosage (1705 mg/d) was higher for patients who took tablets after immersion in a food thickener than for those who took non-immersed tablets (1380 mg/d). The disintegration time and dissolution rate of the immersed tablets were lower than those of non-immersed tablets in vitro. Furthermore, components that constitute the food thickener and diŠerences in composition concentrations diŠerentially aŠect the disintegration and solubility of magnesium oxide tablets. This suggests that commercially available food thickeners are likely to be associated with changes in the degradation of magnesium oxide tablets, and they therefore should be carefully used in certain clinical situations.

Effects of Food Thickeners on the Inhibitory Effect of Voglibose Oral-disintegrating Tablets on Post-prandial Elevation of Blood Sugar Levels

“…1,2) However, there have been reports of undissolved tablets observed in the stool of patients taking magnesium oxide tablets, which have been immersed in a thickening agent; these thickening agents may aŠect the disintegration or dissolution of magnesium oxide. 3) In addition, the thickening agents may also aŠect the disintegration of quick-dissolving tablets such as oral-disintegrating tablets. 4,5) In this report, we examine the eŠect of immersion of a thickening agent on the inhibitory eŠect of frequently administered voglibose oral-disintegrating tablets on the incremental elevation of blood sugar levels, with the aim of improving post-prandial hyperglycemia in diabetic patients.…”

“…3) In addition, the thickening agents may also aŠect the disintegration of quick-dissolving tablets such as oral-disintegrating tablets. 4,5) In this report, we examine the eŠect of immersion of a thickening agent on the inhibitory eŠect of frequently administered voglibose oral-disintegrating tablets on the incremental elevation of blood sugar levels, with the aim of improving post-prandial hyperglycemia in diabetic patients.…”

Effect of Food Thickener on Dissolution and Laxative Activity of Magnesium Oxide Tablets in Mice

“…In light of the current findings, although xanthan gum-based food thickeners are commonly used in medical institutions and nursing-care facilities, they should not be readily mixed with M tablet suspensions and administered to patients. In a previous study, 8) we showed that when Tsuru-Q was mixed in an M tablet suspension, the dissolution rate of MgO was greater than 80% 120 min after the start of the test. The difference with the present study was the length of time that the samples were allowed to stand for.…”

“…In the present study, we allowed all samples to stand for 30 min, whereas previous studies did not specifically set a standing time. Moreover, because interviews conducted with those working in clinical practice revealed that up to 30 min is needed to mix food thickeners in an M tablet suspension before administration to patients, 8) we let the solutions used in the present study stand for 30 min. The results of the two studies, which had differing mixture standing times show that when Tsuru-Q is used, the effects on the dissolution rate of MgO is minimal, directly after mixing with the M tablet suspension, but the dissolution rate decreased when allowed to stand for a long period of time.…”

“…Dissolution tests have shown that the dissolution rate of MgO decreases when MgO tablets are mixed in a food thickener, and by suspending and disintegrating the MgO tablets in an aqueous solution before mixing with the food thickener, the decrease in the dissolution rate of MgO can be avoided. 8) The effect of food thickener on the pharmacokinetics of oral drugs has not been sufficiently investigated. Importantly, none of the studies incorporated the optimized administration of the MgO which has been shown to influence the drug's efficacy in a food thickener.…”