A basic protein fraction capable of inducing experimental allergic neuritis was isolated from peripheral nervous tissues of ox and rabbit. The electrophoretic mobility was lower than that of lysozyme at pH 4.2 and 8.2. The yield was approximately 0.1 g per cent of fresh tissue weight.

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Summary 1) Brain samples obtained by biopsy from the frontal lobes in idiopathic epilepsy patients showed an abnormal distribution of proteins in all five cases tested. 2) Following three questions has been discussed: What is the original pattern of abnormal protein distribution found in the brains of idiopathic epilepsy patients? What significance has the abnormal protein distribution in concern with the predisposition toward epileptic seizures or for the mechanism which leads up to epileptic attacks? Is not the original pattern of abnormal protein distribution really induced by some developmental lesions of the brain?

IT is known that curare can block neuromuscular transmission and also the synaptic transmission in autonomic ganglia. However, the cerebral action of curare is still a matter of controversy. There have been conflicting opinions even about the reason for the absence of blocking action of curare on axonal conduction. NACHMANSOHN (1959) has suggested the existence of a 'receptor' protein for acetylcholine in intact cells, based on studies with isolated electric tissue of electric eel, and he has suggested that there may be strong competition between curare and acetylcholine for the receptor. Recently EHRENPREIS (1959) reported the isolation from the same electric eel tissue of a protein with the properties of an acetylcholine receptor: it formed a highly specific complex with curare and related compounds. The present author has studied the interaction between curare and soluble brain proteins by a 'crossing electrophoresis' technique (NAKAMURA and UEDA, 1958), and interesting results on actions of curare on cerebral grey matter and white matter were obtained.