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In a double-blind clinical trial, 24 patients with advanced chronic liver disease received 1.2 g of nicotinohydroxamic acid daily and 23 patients received 1.5 g of neomycin. Patients receiving nicotinohydroxamic acid showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. Nicotinohydroxamic acid induced some side effects, such as mild diarrhea, constipation and anorexia, but less than in cases of neomycin.

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The micromethod technique for the determination of enzyme activities in liver is out lined. It is demonstrated that the micromethod technique is reliable. G lutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline and acid phosphatases, glucose-6-phosphatase, catalase, aldolase and arginase activities in liver and serum were measured in various liver and malignant diseases.