Glutathione reductase activity in serum and liver tissue of human and rat with hepatic damage.

Kumata, Hirokatsu; Wakui, Kazuo; Sano, Hiroshi; Sugawara, Tomohiro; Lim, Insu; Otsuki, Masao; Ozeki, Tsuneo; Miura, Kiyomi; Yamagata, Shoichi

doi:10.1620/tjem.116.127

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Thus, the rapid increase of SGR at the initial phase and rapid decrease after the attainment of the peak of icterus is not related to the changes in serum bilirubin level. Previously we have observed (Kumata et al 1975) that in -CC14liver damaged rat SGR increased earlier than transaminases and decreased much faster than transaminases. The same pattern of changes was found in the clinical situation in patients with acute hepatitis.…”

Section: Resultsmentioning

confidence: 74%

Clinical significance of serum glutathione reductase in various clinical conditions, especially in liver diseases.

Wakui

Kumata

Tadaki

et al. 1976

Tohoku J. Exp. Med.

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Section: Resultsmentioning

confidence: 74%

Clinical significance of serum glutathione reductase in various clinical conditions, especially in liver diseases.

Wakui

Kumata

Tadaki

et al. 1976

Tohoku J. Exp. Med.

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“…High lipid peroxidation is linked to the state where the balance of oxidative damage and body’s antioxidant repair capacity is altered, with a shift towards oxidative damage leading to apoptosis or necrosis and cell death [ 44 , 45 ]. Glutathione is used in the electron transport system in the liver, and its reduction occurs in the presence of enzyme glutathione reductase [ 46 , 47 ]. Glutathione reductase is an important molecule to prevent oxidative stress and maintains the reduced state of cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of Exposure of Plastic Infant Feeding Bottle Leached Water on Biochemical, Morphological and Oxidative Stress Parameters in Rats

Pant

Ahmad

Naithani

et al. 2020

Toxics

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Bisphenol A (BPA) is leached out from plastic infant feeding bottles that are filled with warm milk/water due to high temperatures, exposing the infants to BPA. The present study aims to understand the effects of ingestion of BPA leached from plastic infant feeding bottle and delineate the underlying mechanisms in rats. In this study, adult rats of Wistar strain were divided into 3 groups. In the first group, the rats consumed normal food and tap water ad libitum. In the second group, the rats ingested BPA (20 µg/kg bodyweight/day, orally). In the third group, the rats drank water leached from plastic infant feeding bottles. After 30days, tests involving biochemical parameters, histopathological examination, and oxidative stress enzyme markers were performed, and the levels of BPA in plastic-leached water were estimated by HPLC analysis. There were significant biochemical changes in the form of increased alkaline phosphatase (ALP), creatine kinase-muscle/brain (CK-MB), and lactate dehydrogenase (LDH) levels in both treated groups as compared to control group, accompanied by structural damage to the vital organs, and lipid peroxidation, glutathione reductase, and catalase activity were also high in the treated groups. Further, the BPA concentration in plastic leached water was estimated to be 0.1 ± 0.02 µg/mL.

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Glutathione reductase activity in serum and liver tissue of human and rat with hepatic damage.

Cited by 2 publications

References 14 publications

Clinical significance of serum glutathione reductase in various clinical conditions, especially in liver diseases.

Clinical significance of serum glutathione reductase in various clinical conditions, especially in liver diseases.

Effect of Exposure of Plastic Infant Feeding Bottle Leached Water on Biochemical, Morphological and Oxidative Stress Parameters in Rats

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