The findings indicate that cultured HCECs transplanted from adult human donor cornea by means of a collagen sheet can retain their function of corneal dehydration in a rabbit model and suggest the feasibility of transplantation for CEC dysfunction using cultured HCECs with a collagen sheet.

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We present a concept of non-Gaussian measurement composed of a non-Gaussian ancillary state, linear optics and adaptive heterodyne measurement, and on the basis of this we also propose a simple scheme of implementing a quantum cubic gate on a traveling light beam. In analysis of the cubic gate in the Heisenberg representation, we find that nonlinearity of the gate is independent from nonclassicality; the nonlinearity is generated solely by a classical nonlinear adaptive control in a measurement-and-feedforward process while the nonclassicality is attached by the non-Gaussian ancilla that suppresses excess noise in the output. By exploiting the noise term as a figure of merit, we consider the optimum non-Gaussian ancilla that can be prepared within reach of current technologies and discuss performance of the gate. It is a crucial step towards experimental implementation of the quantum cubic gate.

Abstract:We develop an experimental scheme based on a continuouswave (cw) laser for generating arbitrary superpositions of photon number states. In this experiment, we successfully generate superposition states of zero to three photons, namely advanced versions of superpositions of two and three coherent states. They are fully compatible with developed quantum teleportation and measurement-based quantum operations with cw lasers. Due to achieved high detection efficiency, we observe, without any loss correction, multiple areas of negativity of Wigner function, which confirm strongly nonclassical nature of the generated states. Haroche, "Quantum Zeno dynamics of a field in a cavity," Phys. Rev. A 86, 032120 (2012).

Conventional LASIK significantly increases ocular higher-order aberrations, which compromise the postoperative contrast sensitivity function.

Exfoliation syndrome (XFS) is the commonest known risk factor for secondary glaucoma and a significant cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A have been previously associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results between populations, and to identify new variants associated with XFS. We identified a rare, protective allele at LOXL1 (p.407Phe, OR = 25, P =2.9 × 10−14) through deep resequencing of XFS cases and controls from 9 countries. This variant results in increased cellular adhesion strength compared to the wild-type (p.407Tyr) allele. A genome-wide association study (GWAS) of XFS cases and controls from 24 countries followed by replication in 18 countries identified seven genome-wide significant loci (P < 5 × 10−8). Index variants at the new loci map to chromosomes 13q12 (POMP), 11q23.3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS, and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology.

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