FUJIE, one of the authors, has previously put forward the gastric hormone productin and concluded with many experimental results that the true nature of productin must be histamine or histamine-like substance which is secreted from the gastric surface cells into the blood. His conclusion on the nature of productin, however, was obtained hitherto with experimental observations by using histamine and with quantitative determinations of histamine in the blood etc., but never in the way of chemical qualitative determination.
Abstract.Three milligram of histamine hydrochloride were injected daily into rats subcutaneously.The injection was performed 1, 15, 30, 45 or 60 times.On each stage, the pancreatic cells and the duodenal epithelial cells were observed before and after the administration of artificial food.The pancreatic cells initiate a production of zymogen granules even in
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