Histochemical Research on the Content in the‘Productin’Vacuoles (FUJIE) of the Gastric Surface Cells. I

Abstract

FUJIE, one of the authors, has previously put forward the gastric hormone productin and concluded with many experimental results that the true nature of productin must be histamine or histamine-like substance which is secreted from the gastric surface cells into the blood. His conclusion on the nature of productin, however, was obtained hitherto with experimental observations by using histamine and with quantitative determinations of histamine in the blood etc., but never in the way of chemical qualitative determination.

Experimental Studies on the Isolated Humoral Factor which Promotes the Secretory Activity of the Gastric Chief Cells and the Exocrine Pancreatic Cells

“…Using histochemical color reactions, the existence of tyrosine and histidine in the surface epithelial cells of gastric mucosa was reported by FUJIE et al (1957). They found the phenol group (tyrosine) and the imidazol group (histidine) in the sub-nuclear region of the cells where productin vacuoles are seen.…”

“…The possibility of these substances as the components of productin was suggested in connection with the histochemical evidence (FUJIE et al 1957) on the occurrence of the phenol group (tyrosine) and the imidazol group (histidine) in the surface epithelial cells of the stomach.…”