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Maternal immune activation (MIA) by an infection is considered to be an important environmental factor of fetal brain development. Recent animal model on MIA induced by polyinosinic:polycytidylic acid, a mimic of viral infection, demonstrates that maternal interleukin 17A (IL-17A) signaling is required for the development of autism spectrum disorder (ASD)-like behaviors of offspring. However, there is little information on bacterial infection. In this study, we aim to elucidate the influence of MIA induced by lipopolysaccharide (LPS) to mimic a bacterial infection on fetal brain development. We demonstrated that LPS-induced MIA promoted ASD-like behaviors in mouse offspring. We further found that LPS exposure induced acute phase immune response: elevation of serum IL-17A levels in MIA mothers, upregulation of Il17a mRNA expression and increase of IL-17A-producing γδ T cells in the uterus, and upregulation of Il17ra mRNA expression in the fetal brain. Blocking of IL-17A in LPS-induced MIA ameliorated ASD-like behaviors in offspring. Our data suggest that bacterial-induced maternal IL-17A pathway promotes ASD-like behaviors in offspring.

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The MEG experiment took data at the Paul Scherrer Institute in the years 2009–2013 to test the violation of the lepton flavor conservation law, which originates from an accidental symmetry that the Standard Model of elementary particle physics has, and published the most stringent limit on the charged lepton flavor violating decay μ+→e+γ: BR(μ+→e+γ) <4.2×10−13 at 90% confidence level. The MEG detector has been upgraded in order to reach a sensitivity of 6×10−14. The basic principle of MEG II is to achieve the highest possible sensitivity using the full muon beam intensity at the Paul Scherrer Institute (7×107 muons/s) with an upgraded detector. The main improvements are better rate capability of all sub-detectors and improved resolutions while keeping the same detector concept. In this paper, we present the current status of the preparation, integration and commissioning of the MEG II detector in the recent engineering runs.

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We present the first direct search for lepton flavour violating muon decay mediated by a new light particle X, $$\upmu ^+ \rightarrow \mathrm {e}^+\mathrm {X}, \mathrm {X} \rightarrow \upgamma \upgamma \ $$ μ + → e + X , X → γ γ . This search uses a dataset resulting from $$7.5\times 10^{14}$$ 7.5 × 10 14 stopped muons collected by the MEG experiment at the Paul Scherrer Institut in the period 2009–2013. No significant excess is found in the mass region 20–45 MeV/c$$^2$$ 2 for lifetimes below 40 ps, and we set the most stringent branching ratio upper limits in the mass region of 20–40 MeV/c$$^2$$ 2 , down to $${\mathcal {O}}(10^{-11})$$ O ( 10 - 11 ) at 90% confidence level.

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