Background About half of stroke survivors experience severe and significant long-term disability. The purpose of this paper is to review the state of the science and to make recommendations for measuring patient-centric outcomes in interventions for motor improvement in the chronic stroke phase. Methods and Results A nine-member expert panel reviewed evidence to identify measures of upper and lower extremity function used to-date as outcomes in trials with patients who experienced a stroke 6 or more months prior to assessment. Outcome measures were screened using StrokEDGE consensus panel recommendations, and evaluated for availability of a published minimal clinically important difference (MCID). Measures meeting these criteria were further evaluated with regard to their level of measurement, psychometric properties, and ability of MCID to capture gains associated with improved function and clinical relevance to patients, to arrive at recommendations. A systematic literature review yielded 115 clinical trials of upper and lower extremity function in chronic stroke that used a total of 34 outcome measures. Seven of these had published MCIDs and were recommended or highly recommended by StrokEDGE. Those are the Fugl-Meyer Upper Extremity and Lower Extremity scales, Wolf Motor Function Test, Action Research Arm Test, Ten Meter and Six Minute Walk Tests, and the Stroke Impact Scale. All had evidence for the psychometric performance, although the strength of evidence for validity varied, especially in chronic stroke populations Fugl-Meyer Upper and Lower Extremity scales showing the strongest evidence for validity. Conclusions The panel recommends that the Fugl-Meyer Upper and Lower Extremity scales be used as primary outcomes in intervention trials targeting motor function in chronic stroke populations. The other six measures are recommended as secondary outcomes.

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