ABSTRACT… Objectives: Diabetes mellitus is very common disease; the oral hypoglycemic drugs are utilized for diabetes. In Asia therapeutic plants are extensively used for cure of widespread variation of illnesses. Objectives: To study the Therapeutic effect of mango seed extract on diabetes Mellitus. Study Design: A prospective study and longitude. Setting: This study was conducted at Jinnah Post graduate Center, Karachi. Period: From June 2016 to June 2017. Material and Methods: Mango seeds were taken out with ethanol and used for study. The antidiabetic action of mango seeds extracts were well-thought-out at 100 and 200 mg/kg b.wt. The antidiabetic effect of mango seeds extracts were matched with tolbutamide 500 mg/ kg b.wt. Result: The ethanolic extract of mango seeds (200 mg/kg) revealed major (p< 0.01) hypoglycemic outcome in fasted diabetic rats, when matched with normal control group. The mango seed extracts were significantly increased insulin level and decreased HbA1c levels at the dose level (100, 200 mg/kg) in alloxone encouraged diabetic rats. Conclusion: The ethanolic extract of mango seeds ensuring important antidabatic outcome compared to aloxone tempted diabetes in albino rats and its stimulating insulin production in pancreas of albino rats.
Objective: The objective of the study was to assess the association of body mass index (BMI) with Activin-A and Inhibin-A (biomarkers) irrespective to age in women with gestational diabetes mellitus (GDM).Methods: This study was a case-controlled study, in which sixty (60) diagnosed cases of gestational diabetic women with and without obesity and thirty (30) pregnant women without diabetes or any other complications were included in the study after taking informed written consent. The duration of the study was from January 2018 to June 2018. The enrolled participants were ninety (90) who were fulfilling the criteria in the duration of the study. Participants were placed into three groups A, B and C. In group A, thirty (30) pregnant females without complications, in group B thirty (30) non-obese pregnant women with gestationaldiabetes and in group C thirty (30) obese pregnant females with gestational diabetes mellitus (GDM). The biophysical parameters including weight, height and blood pressure were measured through standard protocols. Blood tests for biomarkers Activin-A and Inhibin-A levels were measured through Human Activin-A enzyme-linked immunosorbent assay(ELISA) kit and Human Inhibin-A ELISA kit respectively.Results: The results of the study revealed that the biophysical markers Actin-A and Inhibin-A had associations with gestational diabetes, the significant (p-value<0.05) association was observed between Activin-A and body mass index but Inhibin-A had an insignificant association with it. However, the levels of bothbiomarkers (Activin-A and Inhibin-A) were found to be raised in both obese and non-obese gestational diabetic women when compared with normal pregnant women. The secondary outcome of the study is, there is significant (p-value>0.05) relation between age and body mass index of obese GDM.Conclusion: The study concluded that the level of Activin-A was raised significantly (p-value>0.05) in obese and non-obese gestational diabetic women as compared to normal pregnant women and non-significant increases in inhibin-A were observed in obese and non-obese gestational diabetic women as compared to normal pregnant women. A secondary outcome was, that there is significant (p-value>0.05) association found between body mass index and age of the pregnant women.
Objective: To correlate the preventive role of vitamin E levels and platelet count in patients with different grades of pregnancy induced hypertension. The secondary objective was to compare these grades with normal pregnant patients. Study Design and Setting: This study was conducted in Obstetric OPD of Jinnah Postgraduate Medical Centre (JPMC), Karachi, from April 2002 through April 2004. Methodology: The study group included 110 patients divided in three groups as Group A: n=40 Normotensive patients, Group B: n=40 Mild hypertensive (test group I), Group C: n=30 Severe hypertensive (test group II). All women were advised not to take any multivitamin supplements. Result: Serum alpha tocopherol (vitamin E) was significantly low in severe and mild cases (0.32±0.00 mg/dl, 0.74±0.03 mg/dl respectively), when compared with normal pregnant women levels (0.78±0.040). The decreased platelet count (246820±1493.51) in mild cases and (135460±387.2) in severe cases was significant (P<0.01) as compared to the normal pregnant women (348000±574.35). The decrease platelet count values for severe cases were again significant (P<0.01) when compared with mild cases of PIH. Conclusion: In patients with risk of preeclampsia adequate antioxidant nutrients may have a role in cessation of free radicalmediated cell disturbances, and thereby protecting against endothelial cell damage, which is the key factor in preeclampsia development
Background: Preeclampsia is a multifactorial disorder comprising many organs. Oxidative stress (OS) has been intensely linked to its occurrence. Vitamin E, a lipophilic chain breaking antioxidant has been proved to suppress the OS. Present study was designed to investigate antioxidant nutrient profile in patients with different grades of pregnancy induced hypertension (PIH) and to compare them with normal pregnant controls. Methods: The study group comprised 110 patients divided in three groups as Group A (n=40) Normotensive patients, Group B (n=40) Mild hypertensive, Group C (n=30) Severe hypertensive. Vitamin A, B-Carotene, serum alpha tocopherol (vitamin E) and vitamin C levels were analysed. Results: Serum alpha tocopherol (vitamin E) was significantly low in severe and mild cases (0.32±0.00 mg/dl, 0.74±0.03 mg/dl respectively), when compared with normal pregnant women levels (0.78±0.040). All other nutrients were also found to be in reduced quantity for Group C when compared to control group (P value <0.001). Conclusion: It was therefore concluded that in patients with risk of preeclampsia (PE) adequate antioxidant nutrients may have a role in cessation of free radical-mediated cell disturbances, and thereby protecting against endothelial cell damage, which is the key factor in PE development.
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