IntroductionThe natural vitamin E (VE) compounds tocopherol (Toc) and tocotrienol (Tocotri) share common structures with a chromanol head and a phytyl tail. Both compounds interfere with one or more propagation steps of the lipid peroxidation process, which is crucial in therapies of oxidation-induced diseases 1−9) , and therefore the intake from the diet is greatly recommended. However, as natural VE is a lipidsoluble antioxidant, it is lowly soluble in water. To overcome the low affinity in water media, VE is loaded into liposomes or vesicles or solubilized or dispersed by a surfactant. These methodologies based on molecular assembly science have greatly advanced the construction of vitamin E loaded nanoarchitectures for medicinal application 1, 5−8, 10−16) .Meanwhile, VEs in well-established molecular biology research are typically used without stabilizer for the initial assessment, because stabilizers may affect the cell media. A few organic solvents, such as ethanol and dimethylsulfoxide (DMSO) , are permissible as VE additives. VEs are first dissolved in the organic solvent and the VE vehicle consisting of the VE and organic solvent is added as a solu
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