These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.

These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.

1297 patients (30.8%) were found to have one or more symptoms of genetically determined predisposition to disturbed development. The most frequent symptoms were atypical position of tooth buds (12.2%), absence of tooth buds of permanent teeth (9.2%), and displaced teeth (7.0%). 73.5% of the patients had only one symptom, and 26.5% two or more. Microdontia and displaced teeth were associated particularly frequently with other symptoms of predisposition to disturbed development. Genetically determined predisposition to disturbed development of the dentition is accordingly not rare but is of great epidemiological significance and may provide early indications of potential developmental disorders such as missing tooth buds or displacement of teeth.