Epidemiology of Hoffmeister's “Genetically Determined Predisposition to Disturbed Development of the Dentition” in Patients With Cleft Lip and Palate

Abstract

These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.

Correlation between the frequency of eruption disorders for first permanent molars and the occurrence of malocclusions in early mixed dentition

“…In this regard, he is correct in suggesting that the early identification of "minor" deviations in dental development predicts high-risk dental development in these children; this should be taken as a basis for specific therapeutic intervention. Our study findings demonstrate that eruption disorders among the first permanent molars in the upper jaw are an early indication of a Class III developmental tendency [19].…”

“…Insofern ist ihm zuzustimmen, dass das rechtzeitige Erkennen von "kleineren" Abweichungen in der Gebissentwicklung auf eine risikobehaftete Gebissentwicklung bei diesen Kindern schließen lässt und als Grundlage für gezieltes therapeutisches Handeln verstanden werden sollte. Bezogen auf die vorliegende Untersuchung ist die Durchbruchsstörung im 6-Jahrmolarenbereich des Oberkiefers somit ein früher Hinweis auf eine auch progen belastete Gebissentwicklung [19].…”

Dental Development of Chinese Children with Cleft Lip and Palate

“…Moreover, Karsten et al (2005) found that the higher the number of missing second premolars, the greater the length of the cleft was extended. Therefore, clefting may be part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition, because patients with clefts are also likely to present other deficiencies of dental development and tooth eruption (Stahl et al, 2006).…”

Anomalias Dentárias Nas Fissuras Labiais E/Ou Palatinas Não-Sindrômicas: Revisão Da Literatura

“…(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) Tem sido descrito que o desenvolvimento das FL/PNS e dos dentes apresentam semelhanças embriológicas em relação ao tempo e à posição anatômica. (19) Interações complexas entre os tecidos embrionários requerem regulação precisa do movimento celular, crescimento, modelamento e diferenciação tecidual. (18,20) Assim, reconhece-se que eventos como proliferação, diferenciação e apoptose definem as estruturas dentárias e a face, e distúrbios nestes processos, por influências ambientais e/ou genéticas, podem predispor o desenvolvimento de anomalias dentais e também de FL/P.…”