Specific criteria chosen to determine whether items have DIF have an impact on the findings. Criteria based entirely on statistical significance may detect small differences that are clinically negligible.

Background:The literature is inconclusive on the role of antidepressant medications in treating drug dependence. Studies have either not focused on depressed patients or have selected patients with depressive disorders based on cross-sectional symptoms rather than a syndromal diagnosis. A clinical trial of an antidepressant was, therefore, conducted on drug-dependent patients with syndromal depression.

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IRT and the likelihood-based model comparison approach comprise a powerful tool for DIF detection that can aid in the development, refinement, and evaluation of measures for use in ethnically diverse populations.

The fact that many physical function items showed DIF with respect to age, even after adjustment for multiple comparisons, indicates that the instrument may be performing differently for these groups. While the magnitude and impact of DIF at the item and scale level was minimal, caution should be exercised in the use of subsets of these items, as might occur with selection for clinical decisions or computerized adaptive testing. The issues of selection of anchor items, and of criteria for DIF detection, including the integration of significance and magnitude measures remain as issues requiring investigation. Further research is needed regarding the criteria and guidelines appropriate for DIF detection in the context of health-related items.

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